Impact of Preoperative Handgrip Strength on Postoperative Outcome after Radical Gastrectomy for Gastric Cancer Patients
In this study, we investigated whether preoperative low-handgrip strength (HGS) defined by the Asian working group for sarcopenia could be a predictor of postoperative outcomes in patients with gastric cancer. A total of 327 patients who underwent radical gastrectomy for c-stage I–III primary gastri...
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MDPI AG
2022-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/23/7129 |
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| author | Ryota Matsui Noriyuki Inaki Toshikatsu Tsuji Ryo Momosaki Tetsu Fukunaga |
| author_facet | Ryota Matsui Noriyuki Inaki Toshikatsu Tsuji Ryo Momosaki Tetsu Fukunaga |
| author_sort | Ryota Matsui |
| collection | DOAJ |
| description | In this study, we investigated whether preoperative low-handgrip strength (HGS) defined by the Asian working group for sarcopenia could be a predictor of postoperative outcomes in patients with gastric cancer. A total of 327 patients who underwent radical gastrectomy for c-stage I–III primary gastric cancer with pre-operative HGS records were included. The cut-off values of HGS were defined as 28 kg for males and 18 kg for females, with values below and above the cut-off defined as low-HGS and high-HGS, respectively. The primary outcome was infectious complications. We compared the postoperative outcomes of the groups after adjusting for the background using propensity score matching. Of the 327 patients, 246 (75.2%) and 81 (24.8%) were in the high and low-HGS groups, respectively. After adjusting for background, there were 57 patients in both groups. After matching, the low-HGS group had significantly more infectious complications (17.5% vs. 1.8%, <i>p</i> = 0.008). Multivariate analysis of infectious complications in the low-HGS group demonstrated chronic kidney disease and diabetes as independent risk factors (odds ratio 4.390, 95% confidence interval 1.120–17.20, <i>p</i> = 0.034). Preoperative low-HGS according to the Asian criteria was associated with infectious complications after gastrectomy. Chronic kidney disease and diabetes were independent risk factors for infectious complications among patients with low-HGS. |
| first_indexed | 2024-03-09T17:43:17Z |
| format | Article |
| id | doaj.art-2285c984f7a74a82aa6a9263f986267e |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T17:43:17Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-2285c984f7a74a82aa6a9263f986267e2023-11-24T11:23:23ZengMDPI AGJournal of Clinical Medicine2077-03832022-11-011123712910.3390/jcm11237129Impact of Preoperative Handgrip Strength on Postoperative Outcome after Radical Gastrectomy for Gastric Cancer PatientsRyota Matsui0Noriyuki Inaki1Toshikatsu Tsuji2Ryo Momosaki3Tetsu Fukunaga4Department of Gastroenterological Surgery, Ishikawa Prefectural Central Hospital, Kanazawa 920-8530, JapanDepartment of Gastroenterological Surgery, Ishikawa Prefectural Central Hospital, Kanazawa 920-8530, JapanDepartment of Gastroenterological Surgery, Ishikawa Prefectural Central Hospital, Kanazawa 920-8530, JapanDepartment of Rehabilitation Medicine, Mie University Graduate School of Medicine, Mie 514-8507, JapanDepartment of Upper Gastrointestinal Surgery, Juntendo University Hospital, Tokyo 113-8431, JapanIn this study, we investigated whether preoperative low-handgrip strength (HGS) defined by the Asian working group for sarcopenia could be a predictor of postoperative outcomes in patients with gastric cancer. A total of 327 patients who underwent radical gastrectomy for c-stage I–III primary gastric cancer with pre-operative HGS records were included. The cut-off values of HGS were defined as 28 kg for males and 18 kg for females, with values below and above the cut-off defined as low-HGS and high-HGS, respectively. The primary outcome was infectious complications. We compared the postoperative outcomes of the groups after adjusting for the background using propensity score matching. Of the 327 patients, 246 (75.2%) and 81 (24.8%) were in the high and low-HGS groups, respectively. After adjusting for background, there were 57 patients in both groups. After matching, the low-HGS group had significantly more infectious complications (17.5% vs. 1.8%, <i>p</i> = 0.008). Multivariate analysis of infectious complications in the low-HGS group demonstrated chronic kidney disease and diabetes as independent risk factors (odds ratio 4.390, 95% confidence interval 1.120–17.20, <i>p</i> = 0.034). Preoperative low-HGS according to the Asian criteria was associated with infectious complications after gastrectomy. Chronic kidney disease and diabetes were independent risk factors for infectious complications among patients with low-HGS.https://www.mdpi.com/2077-0383/11/23/7129gastric cancerhandgrip strengthmuscle qualitymuscle quantitypostoperative complication |
| spellingShingle | Ryota Matsui Noriyuki Inaki Toshikatsu Tsuji Ryo Momosaki Tetsu Fukunaga Impact of Preoperative Handgrip Strength on Postoperative Outcome after Radical Gastrectomy for Gastric Cancer Patients Journal of Clinical Medicine gastric cancer handgrip strength muscle quality muscle quantity postoperative complication |
| title | Impact of Preoperative Handgrip Strength on Postoperative Outcome after Radical Gastrectomy for Gastric Cancer Patients |
| title_full | Impact of Preoperative Handgrip Strength on Postoperative Outcome after Radical Gastrectomy for Gastric Cancer Patients |
| title_fullStr | Impact of Preoperative Handgrip Strength on Postoperative Outcome after Radical Gastrectomy for Gastric Cancer Patients |
| title_full_unstemmed | Impact of Preoperative Handgrip Strength on Postoperative Outcome after Radical Gastrectomy for Gastric Cancer Patients |
| title_short | Impact of Preoperative Handgrip Strength on Postoperative Outcome after Radical Gastrectomy for Gastric Cancer Patients |
| title_sort | impact of preoperative handgrip strength on postoperative outcome after radical gastrectomy for gastric cancer patients |
| topic | gastric cancer handgrip strength muscle quality muscle quantity postoperative complication |
| url | https://www.mdpi.com/2077-0383/11/23/7129 |
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