The Potential of Dendritic Cell Subsets in the Development of Personalized Immunotherapy for Cancer Treatment
Since the discovery of dendritic cells (DCs) in 1973 by Ralph Steinman, a tremendous amount of knowledge regarding these innate immunity cells has been accumulating. Their role in regulating both innate and adaptive immune processes is gradually being uncovered. DCs are proficient antigen-presenting...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/45/10/509 |
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| author | Anna Valerevna Gorodilova Kristina Viktorovna Kitaeva Ivan Yurevich Filin Yuri Pavlovich Mayasin Chulpan Bulatovna Kharisova Shaza S. Issa Valeriya Vladimirovna Solovyeva Albert Anatolyevich Rizvanov |
| author_facet | Anna Valerevna Gorodilova Kristina Viktorovna Kitaeva Ivan Yurevich Filin Yuri Pavlovich Mayasin Chulpan Bulatovna Kharisova Shaza S. Issa Valeriya Vladimirovna Solovyeva Albert Anatolyevich Rizvanov |
| author_sort | Anna Valerevna Gorodilova |
| collection | DOAJ |
| description | Since the discovery of dendritic cells (DCs) in 1973 by Ralph Steinman, a tremendous amount of knowledge regarding these innate immunity cells has been accumulating. Their role in regulating both innate and adaptive immune processes is gradually being uncovered. DCs are proficient antigen-presenting cells capable of activating naive T-lymphocytes to initiate and generate effective anti-tumor responses. Although DC-based immunotherapy has not yielded significant results, the substantial number of ongoing clinical trials underscores the relevance of DC vaccines, particularly as adjunctive therapy or in combination with other treatment options. This review presents an overview of current knowledge regarding human DCs, their classification, and the functions of distinct DC populations. The stepwise process of developing therapeutic DC vaccines to treat oncological diseases is discussed, along with speculation on the potential of combined therapy approaches and the role of DC vaccines in modern immunotherapy. |
| first_indexed | 2024-03-10T21:20:23Z |
| format | Article |
| id | doaj.art-22871e74ae8f48e39c2467d4388602df |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-10T21:20:23Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-22871e74ae8f48e39c2467d4388602df2023-11-19T16:06:30ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452023-10-0145108053807010.3390/cimb45100509The Potential of Dendritic Cell Subsets in the Development of Personalized Immunotherapy for Cancer TreatmentAnna Valerevna Gorodilova0Kristina Viktorovna Kitaeva1Ivan Yurevich Filin2Yuri Pavlovich Mayasin3Chulpan Bulatovna Kharisova4Shaza S. Issa5Valeriya Vladimirovna Solovyeva6Albert Anatolyevich Rizvanov7Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, RussiaDepartment of Genetics and Biotechnology, St. Petersburg State University, 199034 St. Petersburg, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, RussiaSince the discovery of dendritic cells (DCs) in 1973 by Ralph Steinman, a tremendous amount of knowledge regarding these innate immunity cells has been accumulating. Their role in regulating both innate and adaptive immune processes is gradually being uncovered. DCs are proficient antigen-presenting cells capable of activating naive T-lymphocytes to initiate and generate effective anti-tumor responses. Although DC-based immunotherapy has not yielded significant results, the substantial number of ongoing clinical trials underscores the relevance of DC vaccines, particularly as adjunctive therapy or in combination with other treatment options. This review presents an overview of current knowledge regarding human DCs, their classification, and the functions of distinct DC populations. The stepwise process of developing therapeutic DC vaccines to treat oncological diseases is discussed, along with speculation on the potential of combined therapy approaches and the role of DC vaccines in modern immunotherapy.https://www.mdpi.com/1467-3045/45/10/509dendritic cellsimmunotherapyclinical trialstumor-associated antigencancer |
| spellingShingle | Anna Valerevna Gorodilova Kristina Viktorovna Kitaeva Ivan Yurevich Filin Yuri Pavlovich Mayasin Chulpan Bulatovna Kharisova Shaza S. Issa Valeriya Vladimirovna Solovyeva Albert Anatolyevich Rizvanov The Potential of Dendritic Cell Subsets in the Development of Personalized Immunotherapy for Cancer Treatment Current Issues in Molecular Biology dendritic cells immunotherapy clinical trials tumor-associated antigen cancer |
| title | The Potential of Dendritic Cell Subsets in the Development of Personalized Immunotherapy for Cancer Treatment |
| title_full | The Potential of Dendritic Cell Subsets in the Development of Personalized Immunotherapy for Cancer Treatment |
| title_fullStr | The Potential of Dendritic Cell Subsets in the Development of Personalized Immunotherapy for Cancer Treatment |
| title_full_unstemmed | The Potential of Dendritic Cell Subsets in the Development of Personalized Immunotherapy for Cancer Treatment |
| title_short | The Potential of Dendritic Cell Subsets in the Development of Personalized Immunotherapy for Cancer Treatment |
| title_sort | potential of dendritic cell subsets in the development of personalized immunotherapy for cancer treatment |
| topic | dendritic cells immunotherapy clinical trials tumor-associated antigen cancer |
| url | https://www.mdpi.com/1467-3045/45/10/509 |
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