Mapping Protein–Protein Interactions of the Resistance-Related Bacterial Zeta Toxin–Epsilon Antitoxin Complex (ε2ζ2) with High Affinity Peptide Ligands Using Fluorescence Polarization

Mapping Protein–Protein Interactions of the Resistance-Related Bacterial Zeta Toxin–Epsilon Antitoxin Complex (ε2ζ2) with High Affinity Peptide Ligands Using Fluorescence Polarization

Toxin–antitoxin systems constitute a native survival strategy of pathogenic bacteria and thus are potential targets of antibiotic drugs. Here, we target the Zeta–Epsilon toxin–antitoxin system, which is responsible for the stable maintenance of certain multiresistance plasmids in Gram-positive bacte...

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Bibliographic Details
Main Authors: María Isabel Fernández-Bachiller, Iwona Brzozowska, Norbert Odolczyk, Urszula Zielenkiewicz, Piotr Zielenkiewicz, Jörg Rademann
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:Toxins
Subjects:
protein–protein interactions
toxin–antitoxin system
drug discovery
bacterial resistance
fluorescence polarization
Online Access:http://www.mdpi.com/2072-6651/8/7/222

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http://www.mdpi.com/2072-6651/8/7/222

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