Cholesterol-lowering drugs cause dissolution of cholesterol crystals and disperse Kupffer cell crown-like structures during resolution of NASH

Cholesterol-lowering drugs cause dissolution of cholesterol crystals and disperse Kupffer cell crown-like structures during resolution of NASH

Cholesterol crystals form within hepatocyte lipid droplets in human and experimental nonalcoholic steatohepatitis (NASH) and are the focus of crown-like structures (CLSs) of activated Kupffer cells (KCs). Obese, diabetic Alms1 mutant (foz/foz) mice were a fed high-fat (23%) diet containing 0.2% chol...

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Bibliographic Details
Main Authors: George N. Ioannou, Derrick M. Van Rooyen, Christopher Savard, W. Geoffrey Haigh, Matthew M. Yeh, Narci C. Teoh, Geoffrey C. Farrell
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Journal of Lipid Research
Subjects:
crown-like structure
caspase 1
lipotoxicity
nonalcoholic steatohepatitis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520356133

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