Assessment of some immunological and physiological indicators for infected and uninfected coronavirus disease patients
Background: The most serious respiratory consequences of coronavirus disease (COVID-19) include the common cold, coagulopathy, multiorgan failure, and death. It can also harm essential organs, including the kidney, liver, gastrointestinal tract, lungs, and brain system. Objective: The study’s object...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Medical Journal of Babylon |
| Subjects: | |
| Online Access: | http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2023;volume=20;issue=4;spage=861;epage=866;aulast=AbdulKhaliq |
| _version_ | 1797221261317767168 |
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| author | Roua Jamal AbdulKhaliq M N Ahmed Anas Yahya Ali Hiba M AlKhateeb |
| author_facet | Roua Jamal AbdulKhaliq M N Ahmed Anas Yahya Ali Hiba M AlKhateeb |
| author_sort | Roua Jamal AbdulKhaliq |
| collection | DOAJ |
| description | Background: The most serious respiratory consequences of coronavirus disease (COVID-19) include the common cold, coagulopathy, multiorgan failure, and death. It can also harm essential organs, including the kidney, liver, gastrointestinal tract, lungs, and brain system. Objective: The study’s objectives were to investigate the impact of COVID-19 infection on liver damage by analyzing a range of indicators such as alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, C-reactive protein (CRP), and d-dimer protein. Materials and Methods: To achieve the study’s goal, blood samples were collected from a group of patients (both males and females), and a series of serological tests were performed, including immunological testing and measurements of CRP, d-dimer, and liver function. Results: In this study of 80 patients (age range between 17 and 70 years), the female-to-male ratio in both groups was 20:20. The difference in CRP level between study groups was statistically significant (P ≤ 0.001). The d-dimer level (ng/mL) in patients with infected COVID was significantly higher (P ≤ 0.001) than in the control group, while there was no statistically significant variation in blood liver enzymes between infected and noninfected COVID groups. According to statistical analysis, there is no discernible gender difference between groups of noninfected people and infected patients. Conclusion: The study findings indicate that there are no significant differences between infected males and females when compared to the comparison group; however, there are distinct variances in CRP and d-dimer levels in the infected group. The results of liver function tests and enzyme measurements revealed no significant changes between the infected and healthy groups. |
| first_indexed | 2024-04-24T13:02:37Z |
| format | Article |
| id | doaj.art-228be97791eb496ea662abe50b689a21 |
| institution | Directory Open Access Journal |
| issn | 1812-156X 2312-6760 |
| language | English |
| last_indexed | 2024-04-24T13:02:37Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Babylon |
| spelling | doaj.art-228be97791eb496ea662abe50b689a212024-04-05T10:12:38ZengWolters Kluwer Medknow PublicationsMedical Journal of Babylon1812-156X2312-67602023-01-0120486186610.4103/MJBL.MJBL_781_23Assessment of some immunological and physiological indicators for infected and uninfected coronavirus disease patientsRoua Jamal AbdulKhaliqM N AhmedAnas Yahya AliHiba M AlKhateebBackground: The most serious respiratory consequences of coronavirus disease (COVID-19) include the common cold, coagulopathy, multiorgan failure, and death. It can also harm essential organs, including the kidney, liver, gastrointestinal tract, lungs, and brain system. Objective: The study’s objectives were to investigate the impact of COVID-19 infection on liver damage by analyzing a range of indicators such as alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, C-reactive protein (CRP), and d-dimer protein. Materials and Methods: To achieve the study’s goal, blood samples were collected from a group of patients (both males and females), and a series of serological tests were performed, including immunological testing and measurements of CRP, d-dimer, and liver function. Results: In this study of 80 patients (age range between 17 and 70 years), the female-to-male ratio in both groups was 20:20. The difference in CRP level between study groups was statistically significant (P ≤ 0.001). The d-dimer level (ng/mL) in patients with infected COVID was significantly higher (P ≤ 0.001) than in the control group, while there was no statistically significant variation in blood liver enzymes between infected and noninfected COVID groups. According to statistical analysis, there is no discernible gender difference between groups of noninfected people and infected patients. Conclusion: The study findings indicate that there are no significant differences between infected males and females when compared to the comparison group; however, there are distinct variances in CRP and d-dimer levels in the infected group. The results of liver function tests and enzyme measurements revealed no significant changes between the infected and healthy groups.http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2023;volume=20;issue=4;spage=861;epage=866;aulast=AbdulKhaliqalanine aminotransferase (alt)alkaline phosphatase (alp)angiotensin-converting enzyme 2 receptor (ace2r)aspartate aminotransferase (ast)covid-19 |
| spellingShingle | Roua Jamal AbdulKhaliq M N Ahmed Anas Yahya Ali Hiba M AlKhateeb Assessment of some immunological and physiological indicators for infected and uninfected coronavirus disease patients Medical Journal of Babylon alanine aminotransferase (alt) alkaline phosphatase (alp) angiotensin-converting enzyme 2 receptor (ace2r) aspartate aminotransferase (ast) covid-19 |
| title | Assessment of some immunological and physiological indicators for infected and uninfected coronavirus disease patients |
| title_full | Assessment of some immunological and physiological indicators for infected and uninfected coronavirus disease patients |
| title_fullStr | Assessment of some immunological and physiological indicators for infected and uninfected coronavirus disease patients |
| title_full_unstemmed | Assessment of some immunological and physiological indicators for infected and uninfected coronavirus disease patients |
| title_short | Assessment of some immunological and physiological indicators for infected and uninfected coronavirus disease patients |
| title_sort | assessment of some immunological and physiological indicators for infected and uninfected coronavirus disease patients |
| topic | alanine aminotransferase (alt) alkaline phosphatase (alp) angiotensin-converting enzyme 2 receptor (ace2r) aspartate aminotransferase (ast) covid-19 |
| url | http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2023;volume=20;issue=4;spage=861;epage=866;aulast=AbdulKhaliq |
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