Local symptoms of Hashimoto’s thyroiditis: A systematic review
ObjectiveHashimoto’s thyroiditis (HT) is the most common type of thyroid disease and can cause many different manifestations. The local symptoms of HT are an under-studied area of research. Therefore, the purpose of this study was to investigate the local symptoms of HT and their prevalence.MethodsA...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-01-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1076793/full |
| _version_ | 1797948225872723968 |
|---|---|
| author | Jiaojiao Yuan Jiaojiao Yuan Shuo Qi Shuo Qi Xufan Zhang Xufan Zhang Hezheng Lai Xinyi Li Xinyi Li Chen Xiaoheng Zhe Li Simiao Yao Simiao Yao Zhiguo Ding Zhiguo Ding |
| author_facet | Jiaojiao Yuan Jiaojiao Yuan Shuo Qi Shuo Qi Xufan Zhang Xufan Zhang Hezheng Lai Xinyi Li Xinyi Li Chen Xiaoheng Zhe Li Simiao Yao Simiao Yao Zhiguo Ding Zhiguo Ding |
| author_sort | Jiaojiao Yuan |
| collection | DOAJ |
| description | ObjectiveHashimoto’s thyroiditis (HT) is the most common type of thyroid disease and can cause many different manifestations. The local symptoms of HT are an under-studied area of research. Therefore, the purpose of this study was to investigate the local symptoms of HT and their prevalence.MethodsA systematic review was performed to find articles in PubMed that discuss the local symptoms of HT. Relevant vocabulary terms and key terms included: autoimmune thyroid disease (AITD), hyperthyroidism, hypothyroidism, neck, throat, pharynx, airway, esophagus, breathe, swallow, globus, sleep apnea, symptoms, and quality of life. Two investigators independently screened the eligible studies.ResultsA total of 54 articles fulfilled the inclusion criteria. Of these, 25 were clinical studies, 24 were case reports, and five were reviews. These clinical studies and case reports included a total of 2660 HT patients. There were eight local symptoms related to HT: neck pain (0.02%~16%), voice changes (7%~30%), throat discomfort (20%~43.7%), shortness of breath (28%~50%), dysphagia (29%), goiter-related symptoms (69.44%), sleep apnea, and generally defined compressive symptoms. Due to the use of different outcome measures among all the studies, a meta-analysis of the data could not be performed.ConclusionGoiter symptoms, which are an item on the ThyPRO scales, are the most frequent local symptoms in HT patients, and include neck pain, voice changes, throat discomfort, and dysphagia. These local symptoms should be identified in the clinic and included in the early diagnosis and management of HT, as well as evaluated further to understand their relevance in the pathogenesis of HT. |
| first_indexed | 2024-04-10T21:39:58Z |
| format | Article |
| id | doaj.art-228c63d19ed9436ea06d8dc0c2e0613f |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T21:39:58Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-228c63d19ed9436ea06d8dc0c2e0613f2023-01-19T05:29:02ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-01-011310.3389/fendo.2022.10767931076793Local symptoms of Hashimoto’s thyroiditis: A systematic reviewJiaojiao Yuan0Jiaojiao Yuan1Shuo Qi2Shuo Qi3Xufan Zhang4Xufan Zhang5Hezheng Lai6Xinyi Li7Xinyi Li8Chen Xiaoheng9Zhe Li10Simiao Yao11Simiao Yao12Zhiguo Ding13Zhiguo Ding14Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaThe First Clinical Medical College, Beijing University of Chinese Medicine, Beijing, ChinaDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaSunsimiao Hospital, Beijing University of Chinese Medicine, Tongchuan, Shanxi, ChinaDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaThe First Clinical Medical College, Beijing University of Chinese Medicine, Beijing, ChinaNational Institute of Complementary Medicine, Western Sydney University, Westmead, NSW, AustraliaDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaThe First Clinical Medical College, Beijing University of Chinese Medicine, Beijing, ChinaDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaThe First Clinical Medical College, Beijing University of Chinese Medicine, Beijing, ChinaDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaSunsimiao Hospital, Beijing University of Chinese Medicine, Tongchuan, Shanxi, ChinaObjectiveHashimoto’s thyroiditis (HT) is the most common type of thyroid disease and can cause many different manifestations. The local symptoms of HT are an under-studied area of research. Therefore, the purpose of this study was to investigate the local symptoms of HT and their prevalence.MethodsA systematic review was performed to find articles in PubMed that discuss the local symptoms of HT. Relevant vocabulary terms and key terms included: autoimmune thyroid disease (AITD), hyperthyroidism, hypothyroidism, neck, throat, pharynx, airway, esophagus, breathe, swallow, globus, sleep apnea, symptoms, and quality of life. Two investigators independently screened the eligible studies.ResultsA total of 54 articles fulfilled the inclusion criteria. Of these, 25 were clinical studies, 24 were case reports, and five were reviews. These clinical studies and case reports included a total of 2660 HT patients. There were eight local symptoms related to HT: neck pain (0.02%~16%), voice changes (7%~30%), throat discomfort (20%~43.7%), shortness of breath (28%~50%), dysphagia (29%), goiter-related symptoms (69.44%), sleep apnea, and generally defined compressive symptoms. Due to the use of different outcome measures among all the studies, a meta-analysis of the data could not be performed.ConclusionGoiter symptoms, which are an item on the ThyPRO scales, are the most frequent local symptoms in HT patients, and include neck pain, voice changes, throat discomfort, and dysphagia. These local symptoms should be identified in the clinic and included in the early diagnosis and management of HT, as well as evaluated further to understand their relevance in the pathogenesis of HT.https://www.frontiersin.org/articles/10.3389/fendo.2022.1076793/fullHashimoto’s thyroiditissymptomsprevalencequality of lifehypothyroidism |
| spellingShingle | Jiaojiao Yuan Jiaojiao Yuan Shuo Qi Shuo Qi Xufan Zhang Xufan Zhang Hezheng Lai Xinyi Li Xinyi Li Chen Xiaoheng Zhe Li Simiao Yao Simiao Yao Zhiguo Ding Zhiguo Ding Local symptoms of Hashimoto’s thyroiditis: A systematic review Frontiers in Endocrinology Hashimoto’s thyroiditis symptoms prevalence quality of life hypothyroidism |
| title | Local symptoms of Hashimoto’s thyroiditis: A systematic review |
| title_full | Local symptoms of Hashimoto’s thyroiditis: A systematic review |
| title_fullStr | Local symptoms of Hashimoto’s thyroiditis: A systematic review |
| title_full_unstemmed | Local symptoms of Hashimoto’s thyroiditis: A systematic review |
| title_short | Local symptoms of Hashimoto’s thyroiditis: A systematic review |
| title_sort | local symptoms of hashimoto s thyroiditis a systematic review |
| topic | Hashimoto’s thyroiditis symptoms prevalence quality of life hypothyroidism |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1076793/full |
| work_keys_str_mv | AT jiaojiaoyuan localsymptomsofhashimotosthyroiditisasystematicreview AT jiaojiaoyuan localsymptomsofhashimotosthyroiditisasystematicreview AT shuoqi localsymptomsofhashimotosthyroiditisasystematicreview AT shuoqi localsymptomsofhashimotosthyroiditisasystematicreview AT xufanzhang localsymptomsofhashimotosthyroiditisasystematicreview AT xufanzhang localsymptomsofhashimotosthyroiditisasystematicreview AT hezhenglai localsymptomsofhashimotosthyroiditisasystematicreview AT xinyili localsymptomsofhashimotosthyroiditisasystematicreview AT xinyili localsymptomsofhashimotosthyroiditisasystematicreview AT chenxiaoheng localsymptomsofhashimotosthyroiditisasystematicreview AT zheli localsymptomsofhashimotosthyroiditisasystematicreview AT simiaoyao localsymptomsofhashimotosthyroiditisasystematicreview AT simiaoyao localsymptomsofhashimotosthyroiditisasystematicreview AT zhiguoding localsymptomsofhashimotosthyroiditisasystematicreview AT zhiguoding localsymptomsofhashimotosthyroiditisasystematicreview |