Early Onset Metastatic Colorectal Cancer: Current Insights and Clinical Management of a Rising Condition
Despite a recent overall decrease in colorectal cancer (CRC) incidence and mortality, there has been a significant rise in CRC diagnoses in young adults. Early onset colorectal cancer (EOCRC) is defined as CRC diagnosed before the age of 50. Possible predisposing conditions include not only genetic...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/13/3509 |
| _version_ | 1797591949124829184 |
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| author | Bianca Medici Beatrice Riccò Eugenia Caffari Silvia Zaniboni Massimiliano Salati Andrea Spallanzani Ingrid Garajovà Stefania Benatti Chiara Chiavelli Massimo Dominici Fabio Gelsomino |
| author_facet | Bianca Medici Beatrice Riccò Eugenia Caffari Silvia Zaniboni Massimiliano Salati Andrea Spallanzani Ingrid Garajovà Stefania Benatti Chiara Chiavelli Massimo Dominici Fabio Gelsomino |
| author_sort | Bianca Medici |
| collection | DOAJ |
| description | Despite a recent overall decrease in colorectal cancer (CRC) incidence and mortality, there has been a significant rise in CRC diagnoses in young adults. Early onset colorectal cancer (EOCRC) is defined as CRC diagnosed before the age of 50. Possible predisposing conditions include not only genetic syndromes but also other risk factors, such as microbiome alteration, antibiotic exposure, obesity, diabetes mellitus, and inflammatory bowel disease. EOCRC tends to be diagnosed later than in the older counterpart because of a lack of awareness and the fact that screening for CRC usually starts at the age of 50. Furthermore, CRC in young adults seems to be related to unique molecular features and more aggressive clinical behavior. This paper aims to provide an in-depth review of this poorly understood subject, with a comprehensive review of the state of the art and considerations for future perspectives. |
| first_indexed | 2024-03-11T01:44:52Z |
| format | Article |
| id | doaj.art-228fa9712485489fab891b1661c38103 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T01:44:52Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-228fa9712485489fab891b1661c381032023-11-18T16:18:00ZengMDPI AGCancers2072-66942023-07-011513350910.3390/cancers15133509Early Onset Metastatic Colorectal Cancer: Current Insights and Clinical Management of a Rising ConditionBianca Medici0Beatrice Riccò1Eugenia Caffari2Silvia Zaniboni3Massimiliano Salati4Andrea Spallanzani5Ingrid Garajovà6Stefania Benatti7Chiara Chiavelli8Massimo Dominici9Fabio Gelsomino10Department of Oncology and Hematology, Division of Oncology, University Hospital of Modena, 41124 Modena, ItalyDepartment of Oncology and Hematology, Division of Oncology, University Hospital of Modena, 41124 Modena, ItalyDepartment of Oncology and Hematology, Division of Oncology, University Hospital of Modena, 41124 Modena, ItalyDepartment of Oncology and Hematology, Division of Oncology, University Hospital of Modena, 41124 Modena, ItalyDepartment of Oncology and Hematology, Division of Oncology, University Hospital of Modena, 41124 Modena, ItalyDepartment of Oncology and Hematology, Division of Oncology, University Hospital of Modena, 41124 Modena, ItalyMedical Oncology Unit, University Hospital of Parma, 43100 Parma, ItalyDepartment of Oncology and Hematology, Division of Oncology, University Hospital of Modena, 41124 Modena, ItalyLaboratory of Cellular Therapy, Division of Oncology, Department of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia, 41121 Modena, ItalyDepartment of Oncology and Hematology, Division of Oncology, University Hospital of Modena, 41124 Modena, ItalyDepartment of Oncology and Hematology, Division of Oncology, University Hospital of Modena, 41124 Modena, ItalyDespite a recent overall decrease in colorectal cancer (CRC) incidence and mortality, there has been a significant rise in CRC diagnoses in young adults. Early onset colorectal cancer (EOCRC) is defined as CRC diagnosed before the age of 50. Possible predisposing conditions include not only genetic syndromes but also other risk factors, such as microbiome alteration, antibiotic exposure, obesity, diabetes mellitus, and inflammatory bowel disease. EOCRC tends to be diagnosed later than in the older counterpart because of a lack of awareness and the fact that screening for CRC usually starts at the age of 50. Furthermore, CRC in young adults seems to be related to unique molecular features and more aggressive clinical behavior. This paper aims to provide an in-depth review of this poorly understood subject, with a comprehensive review of the state of the art and considerations for future perspectives.https://www.mdpi.com/2072-6694/15/13/3509colorectal cancerearly onsetscreening |
| spellingShingle | Bianca Medici Beatrice Riccò Eugenia Caffari Silvia Zaniboni Massimiliano Salati Andrea Spallanzani Ingrid Garajovà Stefania Benatti Chiara Chiavelli Massimo Dominici Fabio Gelsomino Early Onset Metastatic Colorectal Cancer: Current Insights and Clinical Management of a Rising Condition Cancers colorectal cancer early onset screening |
| title | Early Onset Metastatic Colorectal Cancer: Current Insights and Clinical Management of a Rising Condition |
| title_full | Early Onset Metastatic Colorectal Cancer: Current Insights and Clinical Management of a Rising Condition |
| title_fullStr | Early Onset Metastatic Colorectal Cancer: Current Insights and Clinical Management of a Rising Condition |
| title_full_unstemmed | Early Onset Metastatic Colorectal Cancer: Current Insights and Clinical Management of a Rising Condition |
| title_short | Early Onset Metastatic Colorectal Cancer: Current Insights and Clinical Management of a Rising Condition |
| title_sort | early onset metastatic colorectal cancer current insights and clinical management of a rising condition |
| topic | colorectal cancer early onset screening |
| url | https://www.mdpi.com/2072-6694/15/13/3509 |
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