Predictors of appropriate therapy in patients with implantable cardioverter-defibrillator for primary prevention of sudden cardiac death
The purpose of this study was to evaluate predictors of appropriate therapy in patients with implantable cardioverter-defibrillators (ICD) for primary prevention of sudden cardiac death. A retrospective cohort of 321 patients with systolic heart failure undergoing ICD placement for primary preventio...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Touch Medical Media
2010-02-01
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| Series: | Heart International |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/hi/article/view/1669 |
| _version_ | 1819072523770265600 |
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| author | Dennis W. Zhu Chad M. House William B. Nelson Imdad Ahmed |
| author_facet | Dennis W. Zhu Chad M. House William B. Nelson Imdad Ahmed |
| author_sort | Dennis W. Zhu |
| collection | DOAJ |
| description | The purpose of this study was to evaluate predictors of appropriate therapy in patients with implantable cardioverter-defibrillators (ICD) for primary prevention of sudden cardiac death. A retrospective cohort of 321 patients with systolic heart failure undergoing ICD placement for primary prevention of sudden cardiac death was queried with a mean follow-up period of 2.6 years. Appropriate ICD therapy was defined as therapy delivered for termination of a ventricular tachyarrhythmia. Appropriate ICD therapy was delivered in 142 (44%) of the patients. In a multivariate model, body mass index ≥28.8 kg/m2 , chronic kidney disease, left ventricular ejection fraction ≤20% and metabolic syndrome were found to be independent predictors of appropriate ICD therapy. Appropriate ICD therapy was associated with higher cardiovascular mortality. These findings show the importance of identification of risk factors, especially metabolic syndrome, in patients following ICD implantation as aggressive treatment of these co-morbidities may decrease appropriate ICD therapy and cardiovascular mortality. |
| first_indexed | 2024-12-21T17:39:05Z |
| format | Article |
| id | doaj.art-228ff04abea44a9caa4b83e9cd364ebf |
| institution | Directory Open Access Journal |
| issn | 1826-1868 2036-2579 |
| language | English |
| last_indexed | 2024-12-21T17:39:05Z |
| publishDate | 2010-02-01 |
| publisher | Touch Medical Media |
| record_format | Article |
| series | Heart International |
| spelling | doaj.art-228ff04abea44a9caa4b83e9cd364ebf2022-12-21T18:55:41ZengTouch Medical MediaHeart International1826-18682036-25792010-02-0151e4e410.4081/hi.2010.e4Predictors of appropriate therapy in patients with implantable cardioverter-defibrillator for primary prevention of sudden cardiac deathDennis W. ZhuChad M. HouseWilliam B. NelsonImdad AhmedThe purpose of this study was to evaluate predictors of appropriate therapy in patients with implantable cardioverter-defibrillators (ICD) for primary prevention of sudden cardiac death. A retrospective cohort of 321 patients with systolic heart failure undergoing ICD placement for primary prevention of sudden cardiac death was queried with a mean follow-up period of 2.6 years. Appropriate ICD therapy was defined as therapy delivered for termination of a ventricular tachyarrhythmia. Appropriate ICD therapy was delivered in 142 (44%) of the patients. In a multivariate model, body mass index ≥28.8 kg/m2 , chronic kidney disease, left ventricular ejection fraction ≤20% and metabolic syndrome were found to be independent predictors of appropriate ICD therapy. Appropriate ICD therapy was associated with higher cardiovascular mortality. These findings show the importance of identification of risk factors, especially metabolic syndrome, in patients following ICD implantation as aggressive treatment of these co-morbidities may decrease appropriate ICD therapy and cardiovascular mortality.http://www.pagepress.org/journals/index.php/hi/article/view/1669ICD therapy,metabolic syndrome,chronic kidney disease, systolic heart failure |
| spellingShingle | Dennis W. Zhu Chad M. House William B. Nelson Imdad Ahmed Predictors of appropriate therapy in patients with implantable cardioverter-defibrillator for primary prevention of sudden cardiac death Heart International ICD therapy,metabolic syndrome,chronic kidney disease, systolic heart failure |
| title | Predictors of appropriate therapy in patients with implantable cardioverter-defibrillator for primary prevention of sudden cardiac death |
| title_full | Predictors of appropriate therapy in patients with implantable cardioverter-defibrillator for primary prevention of sudden cardiac death |
| title_fullStr | Predictors of appropriate therapy in patients with implantable cardioverter-defibrillator for primary prevention of sudden cardiac death |
| title_full_unstemmed | Predictors of appropriate therapy in patients with implantable cardioverter-defibrillator for primary prevention of sudden cardiac death |
| title_short | Predictors of appropriate therapy in patients with implantable cardioverter-defibrillator for primary prevention of sudden cardiac death |
| title_sort | predictors of appropriate therapy in patients with implantable cardioverter defibrillator for primary prevention of sudden cardiac death |
| topic | ICD therapy,metabolic syndrome,chronic kidney disease, systolic heart failure |
| url | http://www.pagepress.org/journals/index.php/hi/article/view/1669 |
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