Women with multiple gestations have an increased risk of development of hypertension in the future
Abstract Background Multiple gestations are associated with an increased incidence of preeclampsia. However, there exists no evidence for an association between multiple gestations and development of hypertension(HTN) later in life. This study aimed to determine whether multiple gestations are assoc...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-07-01
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| Series: | BMC Pregnancy and Childbirth |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12884-021-03992-2 |
| _version_ | 1818922291725074432 |
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| author | Geum Joon Cho Un Suk Jung Ho Yeon Kim Soo Bin Lee Minjeong Kim Ki-Hoon Ahn Sung Won Han Soon-Cheol Hong Hai-Joong Kim Younghan Kim Min-Jeong Oh |
| author_facet | Geum Joon Cho Un Suk Jung Ho Yeon Kim Soo Bin Lee Minjeong Kim Ki-Hoon Ahn Sung Won Han Soon-Cheol Hong Hai-Joong Kim Younghan Kim Min-Jeong Oh |
| author_sort | Geum Joon Cho |
| collection | DOAJ |
| description | Abstract Background Multiple gestations are associated with an increased incidence of preeclampsia. However, there exists no evidence for an association between multiple gestations and development of hypertension(HTN) later in life. This study aimed to determine whether multiple gestations are associated with HTN beyond the peripartum period. Methods In this retrospective nationwide population-based study, women who delivered a baby between January 1, 2007, and December 31, 2008, and underwent a national health screening examination within one year prior to their pregnancy were included. Subsequently, we tracked the occurrence of HTN during follow-up until December 31, 2015, using International Classification of Diseases-10th Revision codes. Results Among 362,821 women who gave birth during the study period, 4,944 (1.36%) women had multiple gestations. The cumulative incidence of HTN was higher in multiple gestations group compared with singleton group (5.95% vs. 3.78%, p < 0.01, respectively). On the Cox proportional hazards models, the risk of HTN was increased in women with multiple gestations (HR 1.35, 95% CI 1.19, 1.54) compared with those with singleton after adjustment for age, primiparity, preeclampsia, atrial fibrillation, body mass index, blood pressure, diabetes mellitus, high total cholesterol, abnormal liver function test, regular exercise, and smoking status. Conclusions Multiple gestations are associated with an increased risk of HTN later in life. Therefore, guidelines for the management of high-risk patients after delivery should be established. |
| first_indexed | 2024-12-20T01:51:13Z |
| format | Article |
| id | doaj.art-228ffcbddf214070ae03e393ec876242 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-12-20T01:51:13Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-228ffcbddf214070ae03e393ec8762422022-12-21T19:57:38ZengBMCBMC Pregnancy and Childbirth1471-23932021-07-012111710.1186/s12884-021-03992-2Women with multiple gestations have an increased risk of development of hypertension in the futureGeum Joon Cho0Un Suk Jung1Ho Yeon Kim2Soo Bin Lee3Minjeong Kim4Ki-Hoon Ahn5Sung Won Han6Soon-Cheol Hong7Hai-Joong Kim8Younghan Kim9Min-Jeong Oh10Department, of Obstetrics and Gynecology, Korea University College of MedicineDepartment of Obstetrics and Gynecology, Hanyang University Guri Hospital, College of Medicine, Hanyang UniversityDepartment, of Obstetrics and Gynecology, Korea University College of MedicineDepartment, of Obstetrics and Gynecology, Korea University College of MedicineDepartment, of Obstetrics and Gynecology, Korea University College of MedicineDepartment, of Obstetrics and Gynecology, Korea University College of MedicineDepartment, of Obstetrics and Gynecology, Korea University College of MedicineDepartment, of Obstetrics and Gynecology, Korea University College of MedicineDepartment, of Obstetrics and Gynecology, Korea University College of MedicineDeparment of Obstetrics and Gynecology, Severance Hospital, Yonsei University Health SystemDepartment, of Obstetrics and Gynecology, Korea University College of MedicineAbstract Background Multiple gestations are associated with an increased incidence of preeclampsia. However, there exists no evidence for an association between multiple gestations and development of hypertension(HTN) later in life. This study aimed to determine whether multiple gestations are associated with HTN beyond the peripartum period. Methods In this retrospective nationwide population-based study, women who delivered a baby between January 1, 2007, and December 31, 2008, and underwent a national health screening examination within one year prior to their pregnancy were included. Subsequently, we tracked the occurrence of HTN during follow-up until December 31, 2015, using International Classification of Diseases-10th Revision codes. Results Among 362,821 women who gave birth during the study period, 4,944 (1.36%) women had multiple gestations. The cumulative incidence of HTN was higher in multiple gestations group compared with singleton group (5.95% vs. 3.78%, p < 0.01, respectively). On the Cox proportional hazards models, the risk of HTN was increased in women with multiple gestations (HR 1.35, 95% CI 1.19, 1.54) compared with those with singleton after adjustment for age, primiparity, preeclampsia, atrial fibrillation, body mass index, blood pressure, diabetes mellitus, high total cholesterol, abnormal liver function test, regular exercise, and smoking status. Conclusions Multiple gestations are associated with an increased risk of HTN later in life. Therefore, guidelines for the management of high-risk patients after delivery should be established.https://doi.org/10.1186/s12884-021-03992-2Multiple gestationHypertensionPreeclampsia |
| spellingShingle | Geum Joon Cho Un Suk Jung Ho Yeon Kim Soo Bin Lee Minjeong Kim Ki-Hoon Ahn Sung Won Han Soon-Cheol Hong Hai-Joong Kim Younghan Kim Min-Jeong Oh Women with multiple gestations have an increased risk of development of hypertension in the future BMC Pregnancy and Childbirth Multiple gestation Hypertension Preeclampsia |
| title | Women with multiple gestations have an increased risk of development of hypertension in the future |
| title_full | Women with multiple gestations have an increased risk of development of hypertension in the future |
| title_fullStr | Women with multiple gestations have an increased risk of development of hypertension in the future |
| title_full_unstemmed | Women with multiple gestations have an increased risk of development of hypertension in the future |
| title_short | Women with multiple gestations have an increased risk of development of hypertension in the future |
| title_sort | women with multiple gestations have an increased risk of development of hypertension in the future |
| topic | Multiple gestation Hypertension Preeclampsia |
| url | https://doi.org/10.1186/s12884-021-03992-2 |
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