Regulation of the bone marrow microenvironment by G-CSF: Effects of G-CSF on acute lymphoblastic leukaemia.
It has been suggested that disruption of the lymphoid niche by G-CSF may be of therapeutic benefit to patients with acute lymphoblastic leukaemia. We used a xenograft model to determine the effect of G-CSF on ALL progression in a minimal residual disease setting. Consistent with the effects on norma...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5690634?pdf=render |
| _version_ | 1818015288604491776 |
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| author | Jordan Basnett Vicki Xie Adam Cisterne Ken Bradstock Linda Bendall |
| author_facet | Jordan Basnett Vicki Xie Adam Cisterne Ken Bradstock Linda Bendall |
| author_sort | Jordan Basnett |
| collection | DOAJ |
| description | It has been suggested that disruption of the lymphoid niche by G-CSF may be of therapeutic benefit to patients with acute lymphoblastic leukaemia. We used a xenograft model to determine the effect of G-CSF on ALL progression in a minimal residual disease setting. Consistent with the effects on normal murine B cell progenitors, G-CSF slowed disease in the majority of ALL xenografts tested, suggesting that G-CSF may provide benefits beyond neutrophil recovery for ALL patients. However, two of eight xenografts demonstrated accelerated disease progression. G-CSF could be detrimental for these patients due to expansion of the malignant clone. |
| first_indexed | 2024-04-14T06:55:00Z |
| format | Article |
| id | doaj.art-2291e7cba0334cd5abfcebea6a64563f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-14T06:55:00Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-2291e7cba0334cd5abfcebea6a64563f2022-12-22T02:06:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-011211e018804210.1371/journal.pone.0188042Regulation of the bone marrow microenvironment by G-CSF: Effects of G-CSF on acute lymphoblastic leukaemia.Jordan BasnettVicki XieAdam CisterneKen BradstockLinda BendallIt has been suggested that disruption of the lymphoid niche by G-CSF may be of therapeutic benefit to patients with acute lymphoblastic leukaemia. We used a xenograft model to determine the effect of G-CSF on ALL progression in a minimal residual disease setting. Consistent with the effects on normal murine B cell progenitors, G-CSF slowed disease in the majority of ALL xenografts tested, suggesting that G-CSF may provide benefits beyond neutrophil recovery for ALL patients. However, two of eight xenografts demonstrated accelerated disease progression. G-CSF could be detrimental for these patients due to expansion of the malignant clone.http://europepmc.org/articles/PMC5690634?pdf=render |
| spellingShingle | Jordan Basnett Vicki Xie Adam Cisterne Ken Bradstock Linda Bendall Regulation of the bone marrow microenvironment by G-CSF: Effects of G-CSF on acute lymphoblastic leukaemia. PLoS ONE |
| title | Regulation of the bone marrow microenvironment by G-CSF: Effects of G-CSF on acute lymphoblastic leukaemia. |
| title_full | Regulation of the bone marrow microenvironment by G-CSF: Effects of G-CSF on acute lymphoblastic leukaemia. |
| title_fullStr | Regulation of the bone marrow microenvironment by G-CSF: Effects of G-CSF on acute lymphoblastic leukaemia. |
| title_full_unstemmed | Regulation of the bone marrow microenvironment by G-CSF: Effects of G-CSF on acute lymphoblastic leukaemia. |
| title_short | Regulation of the bone marrow microenvironment by G-CSF: Effects of G-CSF on acute lymphoblastic leukaemia. |
| title_sort | regulation of the bone marrow microenvironment by g csf effects of g csf on acute lymphoblastic leukaemia |
| url | http://europepmc.org/articles/PMC5690634?pdf=render |
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