Kisspeptin/GPR54 System: What Do We Know About Its Role in Human Reproduction?
Kisspeptin is involved in the control of human reproduction bridging the gap between the sex steroid levels and feedback mechanisms that control the gonadotropin releasing hormone (GnRH) secretion; however, studies considering this peptide and infertility are limited. We conducted a review and criti...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cell Physiol Biochem Press GmbH & Co KG
2018-09-01
|
| Series: | Cellular Physiology and Biochemistry |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/493406 |
| _version_ | 1819027003839348736 |
|---|---|
| author | Camila M. Trevisan Erik Montagna Renato de Oliveira Denise M. Christofolini Caio P. Barbosa Keith A. Crandall Bianca Bianco |
| author_facet | Camila M. Trevisan Erik Montagna Renato de Oliveira Denise M. Christofolini Caio P. Barbosa Keith A. Crandall Bianca Bianco |
| author_sort | Camila M. Trevisan |
| collection | DOAJ |
| description | Kisspeptin is involved in the control of human reproduction bridging the gap between the sex steroid levels and feedback mechanisms that control the gonadotropin releasing hormone (GnRH) secretion; however, studies considering this peptide and infertility are limited. We conducted a review and critical assessment of available evidence considering kisspeptin structure, physiology, function in puberty and reproduction, its role in assisted reproduction treatments, kisspeptin dosage and the impact on KISS1 and GPR54 genes. Literature searches were conducted in PubMed using keywords related to: (i) kisspeptin or receptors, kisspeptin-1 (ii) reproduction or infertility or fertility (iii) gene and (iv) dosage or measurement or quantification or serum level, in human. Kisspeptin is a product of KISS1 gene that binds to a G-protein-coupled receptor (GPR54/KISS1R) stimulating the release of GnRH by hypothalamic neurons, leading to secretion of pituitary gonadotropins (LH and FSH) and sexual steroids, which in turn will act in the gonads to produce the gametes. Kisspeptin is being recognized as a crucial regulator of the onset of puberty, the regulation of sex hormone mediated secretion of gonadotropins, and the control of fertility. Inactivating and activating mutations in both KISS1 or GPR54 genes were associated with hypogonadotropic hypogonadism and precocious puberty. Despite this, studies considering kisspeptin and infertility are scarce. The understanding of the role of kisspeptin may lead to its use as a biomarker in infertility treatments and use in controlled ovarian hyperstimulation. |
| first_indexed | 2024-12-21T05:35:34Z |
| format | Article |
| id | doaj.art-2294db6088df43c183812d9cb9fb64ba |
| institution | Directory Open Access Journal |
| issn | 1015-8987 1421-9778 |
| language | English |
| last_indexed | 2024-12-21T05:35:34Z |
| publishDate | 2018-09-01 |
| publisher | Cell Physiol Biochem Press GmbH & Co KG |
| record_format | Article |
| series | Cellular Physiology and Biochemistry |
| spelling | doaj.art-2294db6088df43c183812d9cb9fb64ba2022-12-21T19:14:25ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782018-09-014941259127610.1159/000493406493406Kisspeptin/GPR54 System: What Do We Know About Its Role in Human Reproduction?Camila M. TrevisanErik MontagnaRenato de OliveiraDenise M. ChristofoliniCaio P. BarbosaKeith A. CrandallBianca BiancoKisspeptin is involved in the control of human reproduction bridging the gap between the sex steroid levels and feedback mechanisms that control the gonadotropin releasing hormone (GnRH) secretion; however, studies considering this peptide and infertility are limited. We conducted a review and critical assessment of available evidence considering kisspeptin structure, physiology, function in puberty and reproduction, its role in assisted reproduction treatments, kisspeptin dosage and the impact on KISS1 and GPR54 genes. Literature searches were conducted in PubMed using keywords related to: (i) kisspeptin or receptors, kisspeptin-1 (ii) reproduction or infertility or fertility (iii) gene and (iv) dosage or measurement or quantification or serum level, in human. Kisspeptin is a product of KISS1 gene that binds to a G-protein-coupled receptor (GPR54/KISS1R) stimulating the release of GnRH by hypothalamic neurons, leading to secretion of pituitary gonadotropins (LH and FSH) and sexual steroids, which in turn will act in the gonads to produce the gametes. Kisspeptin is being recognized as a crucial regulator of the onset of puberty, the regulation of sex hormone mediated secretion of gonadotropins, and the control of fertility. Inactivating and activating mutations in both KISS1 or GPR54 genes were associated with hypogonadotropic hypogonadism and precocious puberty. Despite this, studies considering kisspeptin and infertility are scarce. The understanding of the role of kisspeptin may lead to its use as a biomarker in infertility treatments and use in controlled ovarian hyperstimulation.https://www.karger.com/Article/FullText/493406KisspeptinHuman ReproductionInfertilityKISS1 geneGPR54 geneDosage |
| spellingShingle | Camila M. Trevisan Erik Montagna Renato de Oliveira Denise M. Christofolini Caio P. Barbosa Keith A. Crandall Bianca Bianco Kisspeptin/GPR54 System: What Do We Know About Its Role in Human Reproduction? Cellular Physiology and Biochemistry Kisspeptin Human Reproduction Infertility KISS1 gene GPR54 gene Dosage |
| title | Kisspeptin/GPR54 System: What Do We Know About Its Role in Human Reproduction? |
| title_full | Kisspeptin/GPR54 System: What Do We Know About Its Role in Human Reproduction? |
| title_fullStr | Kisspeptin/GPR54 System: What Do We Know About Its Role in Human Reproduction? |
| title_full_unstemmed | Kisspeptin/GPR54 System: What Do We Know About Its Role in Human Reproduction? |
| title_short | Kisspeptin/GPR54 System: What Do We Know About Its Role in Human Reproduction? |
| title_sort | kisspeptin gpr54 system what do we know about its role in human reproduction |
| topic | Kisspeptin Human Reproduction Infertility KISS1 gene GPR54 gene Dosage |
| url | https://www.karger.com/Article/FullText/493406 |
| work_keys_str_mv | AT camilamtrevisan kisspeptingpr54systemwhatdoweknowaboutitsroleinhumanreproduction AT erikmontagna kisspeptingpr54systemwhatdoweknowaboutitsroleinhumanreproduction AT renatodeoliveira kisspeptingpr54systemwhatdoweknowaboutitsroleinhumanreproduction AT denisemchristofolini kisspeptingpr54systemwhatdoweknowaboutitsroleinhumanreproduction AT caiopbarbosa kisspeptingpr54systemwhatdoweknowaboutitsroleinhumanreproduction AT keithacrandall kisspeptingpr54systemwhatdoweknowaboutitsroleinhumanreproduction AT biancabianco kisspeptingpr54systemwhatdoweknowaboutitsroleinhumanreproduction |