Evaluation of analgesic and anti-inflammatory activity of a combination of tramadol-ibuprofen in experimental animals
Background: Pain is the major concern of patients attending dental clinics, and satisfactory pain relief has always been difficult to achieve. Since the pathophysiology of pain is a complex, central and peripheral nervous system process, combined analgesic regimens with different mechanisms of actio...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Indian Journal of Dental Research |
| Subjects: | |
| Online Access: | http://www.ijdr.in/article.asp?issn=0970-9290;year=2017;volume=28;issue=3;spage=248;epage=251;aulast=Suthakaran |
| _version_ | 1811262650574700544 |
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| author | Chidambarann Suthakaran Muniyagounder K Kayalvizhi Karnam Nithya Thozhudalangudy AR Raja |
| author_facet | Chidambarann Suthakaran Muniyagounder K Kayalvizhi Karnam Nithya Thozhudalangudy AR Raja |
| author_sort | Chidambarann Suthakaran |
| collection | DOAJ |
| description | Background: Pain is the major concern of patients attending dental clinics, and satisfactory pain relief has always been difficult to achieve. Since the pathophysiology of pain is a complex, central and peripheral nervous system process, combined analgesic regimens with different mechanisms of action as a multimodal approach are becoming popular among the clinicians and dentists. Objectives: The aim of the present study was to evaluate the analgesic and anti-inflammatory activity of ibuprofen and tramadol when used alone or in combination in animal models of pain and inflammation. Animals and Methods: The animals were divided into six groups with six animals in each group. Analgesic activity was assessed by hot plate method in rats and by acetic acid-induced writhing test in mice. Paw edema model in rats after induction with 0.1 mL of 1% carrageenan was used to assess the anti-inflammatory activity. Statistical Analysis: Analysis of variance followed by Tukey's honestly significant difference post hoc test was used for statistical analysis. Results and Conclusion: Combined use of tramadol and ibuprofen provided enhanced analgesic and anti-inflammatory effects in animal models of pain and inflammation. |
| first_indexed | 2024-04-12T19:29:28Z |
| format | Article |
| id | doaj.art-22956eb8590149a2bdb3db0eefc0c0c8 |
| institution | Directory Open Access Journal |
| issn | 0970-9290 1998-3603 |
| language | English |
| last_indexed | 2024-04-12T19:29:28Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dental Research |
| spelling | doaj.art-22956eb8590149a2bdb3db0eefc0c0c82022-12-22T03:19:22ZengWolters Kluwer Medknow PublicationsIndian Journal of Dental Research0970-92901998-36032017-01-0128324825110.4103/ijdr.IJDR_731_16Evaluation of analgesic and anti-inflammatory activity of a combination of tramadol-ibuprofen in experimental animalsChidambarann SuthakaranMuniyagounder K KayalvizhiKarnam NithyaThozhudalangudy AR RajaBackground: Pain is the major concern of patients attending dental clinics, and satisfactory pain relief has always been difficult to achieve. Since the pathophysiology of pain is a complex, central and peripheral nervous system process, combined analgesic regimens with different mechanisms of action as a multimodal approach are becoming popular among the clinicians and dentists. Objectives: The aim of the present study was to evaluate the analgesic and anti-inflammatory activity of ibuprofen and tramadol when used alone or in combination in animal models of pain and inflammation. Animals and Methods: The animals were divided into six groups with six animals in each group. Analgesic activity was assessed by hot plate method in rats and by acetic acid-induced writhing test in mice. Paw edema model in rats after induction with 0.1 mL of 1% carrageenan was used to assess the anti-inflammatory activity. Statistical Analysis: Analysis of variance followed by Tukey's honestly significant difference post hoc test was used for statistical analysis. Results and Conclusion: Combined use of tramadol and ibuprofen provided enhanced analgesic and anti-inflammatory effects in animal models of pain and inflammation.http://www.ijdr.in/article.asp?issn=0970-9290;year=2017;volume=28;issue=3;spage=248;epage=251;aulast=SuthakaranAnalgesiaanti-inflammatory activityibuprofentramadol |
| spellingShingle | Chidambarann Suthakaran Muniyagounder K Kayalvizhi Karnam Nithya Thozhudalangudy AR Raja Evaluation of analgesic and anti-inflammatory activity of a combination of tramadol-ibuprofen in experimental animals Indian Journal of Dental Research Analgesia anti-inflammatory activity ibuprofen tramadol |
| title | Evaluation of analgesic and anti-inflammatory activity of a combination of tramadol-ibuprofen in experimental animals |
| title_full | Evaluation of analgesic and anti-inflammatory activity of a combination of tramadol-ibuprofen in experimental animals |
| title_fullStr | Evaluation of analgesic and anti-inflammatory activity of a combination of tramadol-ibuprofen in experimental animals |
| title_full_unstemmed | Evaluation of analgesic and anti-inflammatory activity of a combination of tramadol-ibuprofen in experimental animals |
| title_short | Evaluation of analgesic and anti-inflammatory activity of a combination of tramadol-ibuprofen in experimental animals |
| title_sort | evaluation of analgesic and anti inflammatory activity of a combination of tramadol ibuprofen in experimental animals |
| topic | Analgesia anti-inflammatory activity ibuprofen tramadol |
| url | http://www.ijdr.in/article.asp?issn=0970-9290;year=2017;volume=28;issue=3;spage=248;epage=251;aulast=Suthakaran |
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