Evolutional and developmental anatomical architecture of the left inferior frontal gyrus
The left inferior frontal gyrus (IFG) including Broca's area is involved in the processing of many language subdomains, and thus, research on the evolutional and human developmental characteristics of the left IFG will shed light on how language emerges and maturates. In this study, we used dif...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-11-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811920307540 |
| _version_ | 1818880173134577664 |
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| author | Jiaojiang Wang Yang Yang Xudong Zhao Zhentao Zuo Li-Hai Tan |
| author_facet | Jiaojiang Wang Yang Yang Xudong Zhao Zhentao Zuo Li-Hai Tan |
| author_sort | Jiaojiang Wang |
| collection | DOAJ |
| description | The left inferior frontal gyrus (IFG) including Broca's area is involved in the processing of many language subdomains, and thus, research on the evolutional and human developmental characteristics of the left IFG will shed light on how language emerges and maturates. In this study, we used diffusion magnetic resonance imaging (dMRI) and resting-state functional MRI (fMRI) to investigate the evolutional and developmental patterns of the left IFG in humans (age 6–8, age 11–13, and age 16–18 years) and macaques. Tractography-based parcellation was used to define the subcomponents of left IFG and consistently identified four subregions in both humans and macaques. This parcellation scheme for left IFG in human was supported by specific coactivation patterns and functional characterization for each subregion. During evolution and development, we found increased functional balance, amplitude of low frequency fluctuations, functional integration, and functional couplings. We also observed higher fractional anisotropy values, i.e. better myelination of dorsal and ventral white matter language pathways during evolution and development. We assume that the resting-state functional connectivity and task-related coactivation mapping are associated with hierarchical language processing. Our findings have shown the evolutional and human developmental patterns of left IFG, and will contribute to the understanding of how the human language evolves and how atypical language developmental disorders may occur. |
| first_indexed | 2024-12-19T14:41:45Z |
| format | Article |
| id | doaj.art-2296dc46a57f4dbc97e39478bb626268 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-19T14:41:45Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-2296dc46a57f4dbc97e39478bb6262682022-12-21T20:17:03ZengElsevierNeuroImage1095-95722020-11-01222117268Evolutional and developmental anatomical architecture of the left inferior frontal gyrusJiaojiang Wang0Yang Yang1Xudong Zhao2Zhentao Zuo3Li-Hai Tan4School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 625014, China; Center for Language and Brain, Shenzhen Institute of Neuroscience, Shenzhen 518057, ChinaCAS Key Laboratory of Behavioral Science, Center for Brain Science and Learning Difficulties, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, ChinaState Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, ChinaState Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; Corresponding author.Guangdong-Hongkong-Macau Institute of CNS Regeneration and Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou 510632, China; Center for Language and Brain, Shenzhen Institute of Neuroscience, Shenzhen 518057, China; Corresponding author: Guangdong-Hongkong-Macau Institute of CNS Regeneration and Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, China.The left inferior frontal gyrus (IFG) including Broca's area is involved in the processing of many language subdomains, and thus, research on the evolutional and human developmental characteristics of the left IFG will shed light on how language emerges and maturates. In this study, we used diffusion magnetic resonance imaging (dMRI) and resting-state functional MRI (fMRI) to investigate the evolutional and developmental patterns of the left IFG in humans (age 6–8, age 11–13, and age 16–18 years) and macaques. Tractography-based parcellation was used to define the subcomponents of left IFG and consistently identified four subregions in both humans and macaques. This parcellation scheme for left IFG in human was supported by specific coactivation patterns and functional characterization for each subregion. During evolution and development, we found increased functional balance, amplitude of low frequency fluctuations, functional integration, and functional couplings. We also observed higher fractional anisotropy values, i.e. better myelination of dorsal and ventral white matter language pathways during evolution and development. We assume that the resting-state functional connectivity and task-related coactivation mapping are associated with hierarchical language processing. Our findings have shown the evolutional and human developmental patterns of left IFG, and will contribute to the understanding of how the human language evolves and how atypical language developmental disorders may occur.http://www.sciencedirect.com/science/article/pii/S1053811920307540Left inferior frontal gyrusLanguageParcellationEvolutionDevelopmentMagnetic resonance imaging |
| spellingShingle | Jiaojiang Wang Yang Yang Xudong Zhao Zhentao Zuo Li-Hai Tan Evolutional and developmental anatomical architecture of the left inferior frontal gyrus NeuroImage Left inferior frontal gyrus Language Parcellation Evolution Development Magnetic resonance imaging |
| title | Evolutional and developmental anatomical architecture of the left inferior frontal gyrus |
| title_full | Evolutional and developmental anatomical architecture of the left inferior frontal gyrus |
| title_fullStr | Evolutional and developmental anatomical architecture of the left inferior frontal gyrus |
| title_full_unstemmed | Evolutional and developmental anatomical architecture of the left inferior frontal gyrus |
| title_short | Evolutional and developmental anatomical architecture of the left inferior frontal gyrus |
| title_sort | evolutional and developmental anatomical architecture of the left inferior frontal gyrus |
| topic | Left inferior frontal gyrus Language Parcellation Evolution Development Magnetic resonance imaging |
| url | http://www.sciencedirect.com/science/article/pii/S1053811920307540 |
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