Frequency of Factor V Leiden and Prothrombin Polymorphism in South of Iran
Normal hemostasis requires balanced regulation of prothromboticand antithrombotic factors. Inherited alteration of factor Vand prothrombin gene, the G20210A mutation, increases the resistanceof factor V to degradation and booster production ofprothrombin respectively. These alterations can increase...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2009-06-01
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| Series: | Iranian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | http://ijms.sums.ac.ir/files/PDFfiles/34_2_09-Dr_%20Karimi.pdf |
| _version_ | 1818136385374126080 |
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| author | Javad Dehbozorgian Abdolreza Afrasiabi Majid Yavarian Golam Reza Panahandeh Shahraki Mehran Karimi Mohammadreza Bordbar Pier M. Mannucci |
| author_facet | Javad Dehbozorgian Abdolreza Afrasiabi Majid Yavarian Golam Reza Panahandeh Shahraki Mehran Karimi Mohammadreza Bordbar Pier M. Mannucci |
| author_sort | Javad Dehbozorgian |
| collection | DOAJ |
| description | Normal hemostasis requires balanced regulation of prothromboticand antithrombotic factors. Inherited alteration of factor Vand prothrombin gene, the G20210A mutation, increases the resistanceof factor V to degradation and booster production ofprothrombin respectively. These alterations can increase hypercoagulabilityleading to thrombotic consequences. We aimed toassess the frequencies of these mutations in a group of the populationof southern Iran. In total, 198 healthy volunteers with theage range of 1-64 years were selected and screened for factor VLeiden and prothrombin mutations using polymerase chain reactionand restriction fragment length polymorphism techniques.The carrier frequencies for factor V Leiden and prothrombin mutationin the studied cohort were 4.1% and 3.07%, respectively.In the studied area, the allele frequency of factor V ishigher than the prothrombin G20210A mutation (0.0204 v0.0153). According to the data and Hardy-Weinberger equation,the total risk of thrombosis caused by homozygosity andheterozygosity of factor V Leiden, prothrombin G20210A mutationand compound heterozygosity of these mutations areabout 1 in 500 individuals. |
| first_indexed | 2024-12-11T09:39:34Z |
| format | Article |
| id | doaj.art-2298cf8b0a234ec6af6fcc1e76235518 |
| institution | Directory Open Access Journal |
| issn | 0253-0716 1735-3688 |
| language | English |
| last_indexed | 2024-12-11T09:39:34Z |
| publishDate | 2009-06-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Medical Sciences |
| spelling | doaj.art-2298cf8b0a234ec6af6fcc1e762355182022-12-22T01:12:42ZengShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-07161735-36882009-06-01342137140Frequency of Factor V Leiden and Prothrombin Polymorphism in South of IranJavad DehbozorgianAbdolreza AfrasiabiMajid YavarianGolam Reza Panahandeh ShahrakiMehran KarimiMohammadreza BordbarPier M. MannucciNormal hemostasis requires balanced regulation of prothromboticand antithrombotic factors. Inherited alteration of factor Vand prothrombin gene, the G20210A mutation, increases the resistanceof factor V to degradation and booster production ofprothrombin respectively. These alterations can increase hypercoagulabilityleading to thrombotic consequences. We aimed toassess the frequencies of these mutations in a group of the populationof southern Iran. In total, 198 healthy volunteers with theage range of 1-64 years were selected and screened for factor VLeiden and prothrombin mutations using polymerase chain reactionand restriction fragment length polymorphism techniques.The carrier frequencies for factor V Leiden and prothrombin mutationin the studied cohort were 4.1% and 3.07%, respectively.In the studied area, the allele frequency of factor V ishigher than the prothrombin G20210A mutation (0.0204 v0.0153). According to the data and Hardy-Weinberger equation,the total risk of thrombosis caused by homozygosity andheterozygosity of factor V Leiden, prothrombin G20210A mutationand compound heterozygosity of these mutations areabout 1 in 500 individuals.http://ijms.sums.ac.ir/files/PDFfiles/34_2_09-Dr_%20Karimi.pdfFactor V Leidenthrombosismutationprothrombin |
| spellingShingle | Javad Dehbozorgian Abdolreza Afrasiabi Majid Yavarian Golam Reza Panahandeh Shahraki Mehran Karimi Mohammadreza Bordbar Pier M. Mannucci Frequency of Factor V Leiden and Prothrombin Polymorphism in South of Iran Iranian Journal of Medical Sciences Factor V Leiden thrombosis mutation prothrombin |
| title | Frequency of Factor V Leiden and Prothrombin Polymorphism in South of Iran |
| title_full | Frequency of Factor V Leiden and Prothrombin Polymorphism in South of Iran |
| title_fullStr | Frequency of Factor V Leiden and Prothrombin Polymorphism in South of Iran |
| title_full_unstemmed | Frequency of Factor V Leiden and Prothrombin Polymorphism in South of Iran |
| title_short | Frequency of Factor V Leiden and Prothrombin Polymorphism in South of Iran |
| title_sort | frequency of factor v leiden and prothrombin polymorphism in south of iran |
| topic | Factor V Leiden thrombosis mutation prothrombin |
| url | http://ijms.sums.ac.ir/files/PDFfiles/34_2_09-Dr_%20Karimi.pdf |
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