Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant

Altered serotonin (5-HT) signaling is associated with multiple brain disorders, including major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and autism spectrum disorder (ASD). The presynaptic, high-affinity 5-HT transporter (SERT) tightly regulates 5-HT clearance after release fr...

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Bibliographic Details
Main Authors: Meagan A. Quinlan, Matthew J. Robson, Ran Ye, Kristie L. Rose, Kevin L. Schey, Randy D. Blakely
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
serotonin transporter
SERT interacting proteins
autism spectrum disorder (ASD)
quantitative proteomic analysis
SERT regulation
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00089/full

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