Pharmacologic inhibition of glycolysis prevents the development of lupus by altering the gut microbiome in mice

Pharmacologic inhibition of glycolysis prevents the development of lupus by altering the gut microbiome in mice

Summary: Gut dysbiosis has been associated with lupus pathogenesis, and fecal microbiota transfers (FMT) from lupus-prone mice shown to induce autoimmune activation into healthy mice. The immune cells of lupus patients exhibit an increased glucose metabolism and treatments with 2-deoxy-D-glucose (2D...

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Bibliographic Details
Main Authors: Ahmed S. Elshikha, Yong Ge, Josephine Brown, Nathalie Kanda, Mojgan Zadeh, Georges Abboud, Seung-Chul Choi, Gregg Silverman, Timothy J. Garrett, William L. Clapp, Mansour Mohamadzadeh, Laurence Morel
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:iScience
Subjects:
Pharmaceutical science
Immune system disorder
Microbiome
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223011999

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