Speech Perception Outcomes after Cochlear Implantation in Children with GJB2/DFNB1 associated Deafness
Background: Cochlear implants (CI) for the rehabilitation of patients with profound or total bilateral sensorineural hypoacusis represent the initial use of electrical fields to provide audibility in cases where the use of sound amplifiers does not provide satisfactory results. Aims: To compare s...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2014-03-01
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| Series: | Balkan Medical Journal |
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| Online Access: | http://balkanmedicaljournal.org/text.php?lang=en&id=340 |
| _version_ | 1797915280476733440 |
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| author | Marina Davcheva-Chakar Valentina Ivanovska Emilija Sukarova-Stefanovska Vesna Lazarevska Ilija Filipche Beti Zafirovska |
| author_facet | Marina Davcheva-Chakar Valentina Ivanovska Emilija Sukarova-Stefanovska Vesna Lazarevska Ilija Filipche Beti Zafirovska |
| author_sort | Marina Davcheva-Chakar |
| collection | DOAJ |
| description | Background: Cochlear implants (CI) for the rehabilitation of patients with profound or total bilateral sensorineural hypoacusis represent the initial use of electrical fields to provide audibility in cases where the use of sound amplifiers does not provide satisfactory results.
Aims: To compare speech perception performance after cochlear implantation in children with connexin 26-associated deafness with that of a control group of children with deafness of unknown etiology.
Study Design: Retrospective comparative study.
Methods: During the period from 2006 to , cochlear implantation was performed on 26 children. Eighteen of these children had undergone genetic tests for mutation of the Gap Junction Protein Beta 2 (GJB2) gene. Bi-allelic GJB2 mutations were confirmed in 7 out of 18 examined children. In order to confirm whether genetic factors have influence on speech perception after cochlear implantation, we compared the post-implantation speech performance of seven children with mutations of the GBJ2 (connexin 26) gene with seven other children who had the wild type version of this particular gene. The latter were carefully matched according to the age at cochlear implantation. Speech perception performance was measured before cochlear implantation, and one and two years after implantation. All the patients were arranged in line with the appropriate speech perception category (SPC). Non-parametric tests, Friedman ANOVA and Mann-Whitney’s U test were used for statistical analysis.
Results: Both groups showed similar improvements in speech perception scores after cochlear implantation. Statistical analysis did not confirm significant differences between the groups 12 and 24 months after cochlear implantation.
Conclusion: The results obtained in this study showed an absence of apparent distinctions in the scores of speech perception between the two examined groups and therefore might have significant implications in selecting prognostic indicators of speech perception following cochlear implantation. |
| first_indexed | 2024-04-10T12:40:21Z |
| format | Article |
| id | doaj.art-229b41dcc7354042aac1c8e8fd88abbf |
| institution | Directory Open Access Journal |
| issn | 2146-3123 2146-3131 |
| language | English |
| last_indexed | 2024-04-10T12:40:21Z |
| publishDate | 2014-03-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Balkan Medical Journal |
| spelling | doaj.art-229b41dcc7354042aac1c8e8fd88abbf2023-02-15T16:14:21ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312014-03-01311606310.5152/balkanmedj.2014.9535Speech Perception Outcomes after Cochlear Implantation in Children with GJB2/DFNB1 associated DeafnessMarina Davcheva-Chakar0Valentina Ivanovska1Emilija Sukarova-Stefanovska2Vesna Lazarevska3Ilija Filipche4Beti Zafirovska5Department of Audiology, University ENT Clinic, Skopje, Republic of MacedoniaDepartment of Audiology, University ENT Clinic, Skopje, Republic of MacedoniaResearch Center of Genetic Engineering and Biotechnology “Georgi D. Efremov”, Skopje, Republic of MacedoniaHearing and Speech Rehabilitation Center, Skopje, Republic of MacedoniaMacedonian Academy of Sciences and Arts, Skopje, Republic of MacedoniaInstitute of Epidemiology, Medical Faculty, Skopje, Republic of MacedoniaBackground: Cochlear implants (CI) for the rehabilitation of patients with profound or total bilateral sensorineural hypoacusis represent the initial use of electrical fields to provide audibility in cases where the use of sound amplifiers does not provide satisfactory results. Aims: To compare speech perception performance after cochlear implantation in children with connexin 26-associated deafness with that of a control group of children with deafness of unknown etiology. Study Design: Retrospective comparative study. Methods: During the period from 2006 to , cochlear implantation was performed on 26 children. Eighteen of these children had undergone genetic tests for mutation of the Gap Junction Protein Beta 2 (GJB2) gene. Bi-allelic GJB2 mutations were confirmed in 7 out of 18 examined children. In order to confirm whether genetic factors have influence on speech perception after cochlear implantation, we compared the post-implantation speech performance of seven children with mutations of the GBJ2 (connexin 26) gene with seven other children who had the wild type version of this particular gene. The latter were carefully matched according to the age at cochlear implantation. Speech perception performance was measured before cochlear implantation, and one and two years after implantation. All the patients were arranged in line with the appropriate speech perception category (SPC). Non-parametric tests, Friedman ANOVA and Mann-Whitney’s U test were used for statistical analysis. Results: Both groups showed similar improvements in speech perception scores after cochlear implantation. Statistical analysis did not confirm significant differences between the groups 12 and 24 months after cochlear implantation. Conclusion: The results obtained in this study showed an absence of apparent distinctions in the scores of speech perception between the two examined groups and therefore might have significant implications in selecting prognostic indicators of speech perception following cochlear implantation.http://balkanmedicaljournal.org/text.php?lang=en&id=340Cochlear implantationconnexin 26deafnessGJB2speech perception |
| spellingShingle | Marina Davcheva-Chakar Valentina Ivanovska Emilija Sukarova-Stefanovska Vesna Lazarevska Ilija Filipche Beti Zafirovska Speech Perception Outcomes after Cochlear Implantation in Children with GJB2/DFNB1 associated Deafness Balkan Medical Journal Cochlear implantation connexin 26 deafness GJB2 speech perception |
| title | Speech Perception Outcomes after Cochlear Implantation in Children with GJB2/DFNB1 associated Deafness |
| title_full | Speech Perception Outcomes after Cochlear Implantation in Children with GJB2/DFNB1 associated Deafness |
| title_fullStr | Speech Perception Outcomes after Cochlear Implantation in Children with GJB2/DFNB1 associated Deafness |
| title_full_unstemmed | Speech Perception Outcomes after Cochlear Implantation in Children with GJB2/DFNB1 associated Deafness |
| title_short | Speech Perception Outcomes after Cochlear Implantation in Children with GJB2/DFNB1 associated Deafness |
| title_sort | speech perception outcomes after cochlear implantation in children with gjb2 dfnb1 associated deafness |
| topic | Cochlear implantation connexin 26 deafness GJB2 speech perception |
| url | http://balkanmedicaljournal.org/text.php?lang=en&id=340 |
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