Dermatan sulfate reduces monocyte chemoattractant protein 1 and TGF-β production, as well as macrophage recruitment and myofibroblast accumulation in mice with unilateral ureteral obstruction

Dermatan sulfate reduces monocyte chemoattractant protein 1 and TGF-β production, as well as macrophage recruitment and myofibroblast accumulation in mice with unilateral ureteral obstruction

Selectins play an essential role in most inflammatory reactions, mediating the initial leukocyte-rolling event on activated endothelium. Heparin and dermatan sulfate (DS) bind and block P- and L-selectin function in vitro. Recently, we reported that subcutaneous administration of DS inhibits colon i...

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Bibliographic Details
Main Authors: C.L.R. Belmiro, R.G. Gonçalves, E.O. Kozlowski, A.F. Werneck, C.M. Takyia, M. Leite-Jr., M.S.G. Pavão
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2011-07-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Glycosaminoglycans
Dermatan sulfate
Kidney
Inflammation
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000700003&lng=en&tlng=en

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