Bevacizumab: Off-label use in ophthalmology
Bevacizumab is a full-length, humanized monoclonal antibody directed against all the biologically active isoforms of vascular endothelial growth factor (VEGF-A). The antibody was initially designed and studied as an anti-angiogenic strategy to treat a variety of solid tumors. After approval by the U...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2007-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2007;volume=55;issue=6;spage=417;epage=420;aulast=Grisanti |
| _version_ | 1819315824737910784 |
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| author | Grisanti Salvatore Ziemssen Focke |
| author_facet | Grisanti Salvatore Ziemssen Focke |
| author_sort | Grisanti Salvatore |
| collection | DOAJ |
| description | Bevacizumab is a full-length, humanized monoclonal antibody directed against all the biologically active isoforms of vascular endothelial growth factor (VEGF-A). The antibody was initially designed and studied as an anti-angiogenic strategy to treat a variety of solid tumors. After approval by the US Food and Drug Administration, bevacizumab gained access into ophthalmology to treat various types of neovascular diseases. Since the first report in 2005 more than 100 publications share the experience with bevacizumab in ophthalmology. Two authors independently assessed the research results from Pubmed to April 2007. The reference list is a selection of key publications related to the issue. Currently, there is no well-designed randomized controlled trial yet to establish the efficacy and safety of intraocular bevacizumab for any ocular disease in spite of its assumed characteristics representing the most cost-effective VEGF inhibitor. |
| first_indexed | 2024-12-24T10:06:15Z |
| format | Article |
| id | doaj.art-22a1f10901ca4ea58cb432e9cfe5057f |
| institution | Directory Open Access Journal |
| issn | 0301-4738 |
| language | English |
| last_indexed | 2024-12-24T10:06:15Z |
| publishDate | 2007-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-22a1f10901ca4ea58cb432e9cfe5057f2022-12-21T17:00:47ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47382007-01-01556417420Bevacizumab: Off-label use in ophthalmologyGrisanti SalvatoreZiemssen FockeBevacizumab is a full-length, humanized monoclonal antibody directed against all the biologically active isoforms of vascular endothelial growth factor (VEGF-A). The antibody was initially designed and studied as an anti-angiogenic strategy to treat a variety of solid tumors. After approval by the US Food and Drug Administration, bevacizumab gained access into ophthalmology to treat various types of neovascular diseases. Since the first report in 2005 more than 100 publications share the experience with bevacizumab in ophthalmology. Two authors independently assessed the research results from Pubmed to April 2007. The reference list is a selection of key publications related to the issue. Currently, there is no well-designed randomized controlled trial yet to establish the efficacy and safety of intraocular bevacizumab for any ocular disease in spite of its assumed characteristics representing the most cost-effective VEGF inhibitor.http://www.ijo.in/article.asp?issn=0301-4738;year=2007;volume=55;issue=6;spage=417;epage=420;aulast=GrisantiBevacizumabintravitreal injectionneovascular ocular disease |
| spellingShingle | Grisanti Salvatore Ziemssen Focke Bevacizumab: Off-label use in ophthalmology Indian Journal of Ophthalmology Bevacizumab intravitreal injection neovascular ocular disease |
| title | Bevacizumab: Off-label use in ophthalmology |
| title_full | Bevacizumab: Off-label use in ophthalmology |
| title_fullStr | Bevacizumab: Off-label use in ophthalmology |
| title_full_unstemmed | Bevacizumab: Off-label use in ophthalmology |
| title_short | Bevacizumab: Off-label use in ophthalmology |
| title_sort | bevacizumab off label use in ophthalmology |
| topic | Bevacizumab intravitreal injection neovascular ocular disease |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2007;volume=55;issue=6;spage=417;epage=420;aulast=Grisanti |
| work_keys_str_mv | AT grisantisalvatore bevacizumabofflabeluseinophthalmology AT ziemssenfocke bevacizumabofflabeluseinophthalmology |