Evaluation of the Expression Intensity of Glucose Transporter-1 Marker and its Diagnostic Value in Differentiating Between Borderline and Malignant Ovarian Epithelial Tumors
Background: Ovarian cancer ranks second among gynecological cancers worldwide. This study aimed to compare the glucose transporter-1 (GLUT-1) expression in benign, borderline, and malignant ovarian epithelial tumors and evaluate GLUT-1 expression as a diagnostic tool for distinguishing tumors in the...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hormozgan University of Medical Sciences
2023-04-01
|
| Series: | Disease and Diagnosis |
| Subjects: | |
| Online Access: | https://ddj.hums.ac.ir/PDF/ddj-12-63.pdf |
| _version_ | 1797737694710726656 |
|---|---|
| author | Siamak Naji Hadadi Hale Ayatollahi Masoumeh Noushyar |
| author_facet | Siamak Naji Hadadi Hale Ayatollahi Masoumeh Noushyar |
| author_sort | Siamak Naji Hadadi |
| collection | DOAJ |
| description | Background: Ovarian cancer ranks second among gynecological cancers worldwide. This study aimed to compare the glucose transporter-1 (GLUT-1) expression in benign, borderline, and malignant ovarian epithelial tumors and evaluate GLUT-1 expression as a diagnostic tool for distinguishing tumors in the ovary. Materials and Methods: This descriptive-analytical cross-sectional study analyzed 69 pathological samples of patients diagnosed with ovarian epithelial tumors who underwent oophorectomy. Immunohistochemical staining was performed using GLUT-1 antibody. The intensity of cell membrane staining and the proportion of positive neoplastic cells were graded to score immunostaining. Chi-square/Fisher’s exact test was used to analyze the data. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV), and staining accuracy for GLUT-1 in distinguishing borderline from invasive tumors were calculated by standard methods (P<0.05). Results: In all benign tumors, GLUT-1 staining was negative. In addition, weak staining intensity was observed in 38.5% of borderline tumors, and 96% of invasive tumors had strong staining intensity (P<0.001). Strong GLUT-1 staining was found in 94.7% of Papillary Serous Carcinoma, 9/1% of Borderline Serous tumors, 100% of Brenner tumors, and clear cell carcinoma. The results demonstrated a high diagnostic value of GLUT-1 expression intensity in differentiating between borderline and malignant ovarian epithelial tumors (Accuracy: 97.10, Sensitivity: 96%, Specificity: 97.73). Conclusion: Overall, GLUT-1 expression could help distinguish benign from borderline, especially borderline from malignant ovarian epithelial tumors. Thus, it seems that it provides useful prognostic information, particularly for the borderline category. |
| first_indexed | 2024-03-12T13:32:08Z |
| format | Article |
| id | doaj.art-22a247e784d24b2b814faa2775778727 |
| institution | Directory Open Access Journal |
| issn | 2717-3232 |
| language | English |
| last_indexed | 2024-03-12T13:32:08Z |
| publishDate | 2023-04-01 |
| publisher | Hormozgan University of Medical Sciences |
| record_format | Article |
| series | Disease and Diagnosis |
| spelling | doaj.art-22a247e784d24b2b814faa27757787272023-08-24T07:47:07ZengHormozgan University of Medical SciencesDisease and Diagnosis2717-32322023-04-01122636910.34172/ddj.2023.441ddj-441Evaluation of the Expression Intensity of Glucose Transporter-1 Marker and its Diagnostic Value in Differentiating Between Borderline and Malignant Ovarian Epithelial TumorsSiamak Naji Hadadi0Hale Ayatollahi1Masoumeh Noushyar2Department of Pathology, Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran.Department of Gynecology and Obstetrics, Kosar Hospital, Urmia University of Medical Sciences, Urmia, Iran.Department of Pathology, Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran.Background: Ovarian cancer ranks second among gynecological cancers worldwide. This study aimed to compare the glucose transporter-1 (GLUT-1) expression in benign, borderline, and malignant ovarian epithelial tumors and evaluate GLUT-1 expression as a diagnostic tool for distinguishing tumors in the ovary. Materials and Methods: This descriptive-analytical cross-sectional study analyzed 69 pathological samples of patients diagnosed with ovarian epithelial tumors who underwent oophorectomy. Immunohistochemical staining was performed using GLUT-1 antibody. The intensity of cell membrane staining and the proportion of positive neoplastic cells were graded to score immunostaining. Chi-square/Fisher’s exact test was used to analyze the data. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV), and staining accuracy for GLUT-1 in distinguishing borderline from invasive tumors were calculated by standard methods (P<0.05). Results: In all benign tumors, GLUT-1 staining was negative. In addition, weak staining intensity was observed in 38.5% of borderline tumors, and 96% of invasive tumors had strong staining intensity (P<0.001). Strong GLUT-1 staining was found in 94.7% of Papillary Serous Carcinoma, 9/1% of Borderline Serous tumors, 100% of Brenner tumors, and clear cell carcinoma. The results demonstrated a high diagnostic value of GLUT-1 expression intensity in differentiating between borderline and malignant ovarian epithelial tumors (Accuracy: 97.10, Sensitivity: 96%, Specificity: 97.73). Conclusion: Overall, GLUT-1 expression could help distinguish benign from borderline, especially borderline from malignant ovarian epithelial tumors. Thus, it seems that it provides useful prognostic information, particularly for the borderline category.https://ddj.hums.ac.ir/PDF/ddj-12-63.pdfovarian epithelial tumorsimmunohistochemicalglut-1benignborderlinemalignant |
| spellingShingle | Siamak Naji Hadadi Hale Ayatollahi Masoumeh Noushyar Evaluation of the Expression Intensity of Glucose Transporter-1 Marker and its Diagnostic Value in Differentiating Between Borderline and Malignant Ovarian Epithelial Tumors Disease and Diagnosis ovarian epithelial tumors immunohistochemical glut-1 benign borderline malignant |
| title | Evaluation of the Expression Intensity of Glucose Transporter-1 Marker and its Diagnostic Value in Differentiating Between Borderline and Malignant Ovarian Epithelial Tumors |
| title_full | Evaluation of the Expression Intensity of Glucose Transporter-1 Marker and its Diagnostic Value in Differentiating Between Borderline and Malignant Ovarian Epithelial Tumors |
| title_fullStr | Evaluation of the Expression Intensity of Glucose Transporter-1 Marker and its Diagnostic Value in Differentiating Between Borderline and Malignant Ovarian Epithelial Tumors |
| title_full_unstemmed | Evaluation of the Expression Intensity of Glucose Transporter-1 Marker and its Diagnostic Value in Differentiating Between Borderline and Malignant Ovarian Epithelial Tumors |
| title_short | Evaluation of the Expression Intensity of Glucose Transporter-1 Marker and its Diagnostic Value in Differentiating Between Borderline and Malignant Ovarian Epithelial Tumors |
| title_sort | evaluation of the expression intensity of glucose transporter 1 marker and its diagnostic value in differentiating between borderline and malignant ovarian epithelial tumors |
| topic | ovarian epithelial tumors immunohistochemical glut-1 benign borderline malignant |
| url | https://ddj.hums.ac.ir/PDF/ddj-12-63.pdf |
| work_keys_str_mv | AT siamaknajihadadi evaluationoftheexpressionintensityofglucosetransporter1markeranditsdiagnosticvalueindifferentiatingbetweenborderlineandmalignantovarianepithelialtumors AT haleayatollahi evaluationoftheexpressionintensityofglucosetransporter1markeranditsdiagnosticvalueindifferentiatingbetweenborderlineandmalignantovarianepithelialtumors AT masoumehnoushyar evaluationoftheexpressionintensityofglucosetransporter1markeranditsdiagnosticvalueindifferentiatingbetweenborderlineandmalignantovarianepithelialtumors |