DNA Repair Mechanisms, Protein Interactions and Therapeutic Targeting of the MRN Complex
Repair of a DNA double-strand break relies upon a pathway of proteins to identify damage, regulate cell cycle checkpoints, and repair the damage. This process is initiated by a sensor protein complex, the MRN complex, comprised of three proteins-MRE11, RAD50, and NBS1. After a double-stranded break,...
Main Authors: | Claire McCarthy-Leo, Fatima Darwiche, Michael A. Tainsky |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-10-01
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Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/14/21/5278 |
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