Key Features Relevant to Select Antigens and TCR From the MHC-Mismatched Repertoire to Treat Cancer

Key Features Relevant to Select Antigens and TCR From the MHC-Mismatched Repertoire to Treat Cancer

Adoptive transfer of T cells transgenic for tumor-reactive T-cell receptors (TCR) is an attractive immunotherapeutic approach. However, clinical translation is so far limited due to challenges in the identification of suitable target antigens as well as TCRs that are concurrent safe and efficient. D...

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Bibliographic Details
Main Authors: Stefan Audehm, Manuel Glaser, Matteo Pecoraro, Eva Bräunlein, Sabine Mall, Richard Klar, Manuel Effenberger, Julian Albers, Henrique de Oliveira Bianchi, Janet Peper, Nahid Yusufi, Dirk H. Busch, Stefan Stevanović, Matthias Mann, Iris Antes, Angela M. Krackhardt
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
T-cell receptor (TCR)
peptide-MHC modeling (p-MHC modeling)
adoptive T-cell transfer therapy
TCR cell therapy
TCR identification
TCR characterization
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01485/full

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