Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols
Acute Lymphoblastic Leukemia is a very aggressive malignant disorder of lymphoid cells in adults, with recurrence (30 to 60% of the cases) after the initial treatment. Until this moment, there is no gold standard therapy for the treatment of adult patients with acute relapsed/refractory lymphoblasti...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2020-04-01
|
| Series: | International Journal of Hematology-Oncology and Stem Cell Research |
| Subjects: | |
| Online Access: | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1161 |
| _version_ | 1827843275150589952 |
|---|---|
| author | Flávia Tobaldini Russo Maria Cristina Martins de Almeida Macedo Pedro Amoedo Fernandes Larissa Yukari Okada Lucas Augusto Monetta da Silva Camila Menin Simões Jamilla Neves Cavalcante Aline de Almeida Simões Manuella de Souza Sampaio Almeida Maricy Almeida Viol Ferreira Lopes Roberto Luiz da Silva |
| author_facet | Flávia Tobaldini Russo Maria Cristina Martins de Almeida Macedo Pedro Amoedo Fernandes Larissa Yukari Okada Lucas Augusto Monetta da Silva Camila Menin Simões Jamilla Neves Cavalcante Aline de Almeida Simões Manuella de Souza Sampaio Almeida Maricy Almeida Viol Ferreira Lopes Roberto Luiz da Silva |
| author_sort | Flávia Tobaldini Russo |
| collection | DOAJ |
| description | Acute Lymphoblastic Leukemia is a very aggressive malignant disorder of lymphoid cells in adults, with recurrence (30 to 60% of the cases) after the initial treatment. Until this moment, there is no gold standard therapy for the treatment of adult patients with acute relapsed/refractory lymphoblastic leukemia. In this case report, we describe two cases of relapsed leukemia: one of lymphocytic leukemia B and one of trilineage leukemia, which presented a satisfactory response to treatment with Bortezomib associated with Vincristine, Dexamethasone, and Bendamustine. |
| first_indexed | 2024-03-12T08:22:26Z |
| format | Article |
| id | doaj.art-22a47d186e044d818575fed902ce0479 |
| institution | Directory Open Access Journal |
| issn | 2008-2207 |
| language | English |
| last_indexed | 2024-03-12T08:22:26Z |
| publishDate | 2020-04-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | International Journal of Hematology-Oncology and Stem Cell Research |
| spelling | doaj.art-22a47d186e044d818575fed902ce04792023-09-02T18:18:20ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-22072020-04-0114210.18502/ijhoscr.v14i2.2676Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue ProtocolsFlávia Tobaldini Russo0Maria Cristina Martins de Almeida Macedo1Pedro Amoedo Fernandes2Larissa Yukari Okada3Lucas Augusto Monetta da Silva4Camila Menin Simões5Jamilla Neves Cavalcante6Aline de Almeida Simões7Manuella de Souza Sampaio Almeida8Maricy Almeida Viol Ferreira Lopes9Roberto Luiz da Silva101) Instituto Brasileiro de Controle do Câncer (IBCC), São Paulo, Brazil 2) Bio Sana`s serviços Médicos, São Paulo, Brazil1) Instituto Brasileiro de Controle do Câncer (IBCC), São Paulo, Brazil 2) Bio Sana`s serviços Médicos, São Paulo, Brazil1) Instituto Brasileiro de Controle do Câncer (IBCC), São Paulo, Brazil 2) Bio Sana`s serviços Médicos, São Paulo, Brazil1) Instituto Brasileiro de Controle do Câncer (IBCC), São Paulo, Brazil 2) Bio Sana`s serviços Médicos, São Paulo, BrazilFaculdade de Ciências Médicas Santa Casa de São Paulo, São Paulo, Brazil1) Instituto Brasileiro de Controle do Câncer (IBCC), São Paulo, Brazil 2) Bio Sana`s serviços Médicos, São Paulo, Brazil1) Instituto Brasileiro de Controle do Câncer (IBCC), São Paulo, Brazil 2) Bio Sana`s serviços Médicos, São Paulo, Brazil1) Instituto Brasileiro de Controle do Câncer (IBCC), São Paulo, Brazil 2) Bio Sana`s serviços Médicos, São Paulo, Brazil1) Instituto Brasileiro de Controle do Câncer (IBCC), São Paulo, Brazil 2) Bio Sana`s serviços Médicos, São Paulo, Brazil1) Instituto Brasileiro de Controle do Câncer (IBCC), São Paulo, Brazil 2) Bio Sana`s serviços Médicos, São Paulo, Brazil1) Instituto Brasileiro de Controle do Câncer (IBCC), São Paulo, Brazil 2) Bio Sana`s serviços Médicos, São Paulo, BrazilAcute Lymphoblastic Leukemia is a very aggressive malignant disorder of lymphoid cells in adults, with recurrence (30 to 60% of the cases) after the initial treatment. Until this moment, there is no gold standard therapy for the treatment of adult patients with acute relapsed/refractory lymphoblastic leukemia. In this case report, we describe two cases of relapsed leukemia: one of lymphocytic leukemia B and one of trilineage leukemia, which presented a satisfactory response to treatment with Bortezomib associated with Vincristine, Dexamethasone, and Bendamustine.https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1161Acute Lymphoblastic Leukemia; Lymphoid cells; Relapsed leukemia |
| spellingShingle | Flávia Tobaldini Russo Maria Cristina Martins de Almeida Macedo Pedro Amoedo Fernandes Larissa Yukari Okada Lucas Augusto Monetta da Silva Camila Menin Simões Jamilla Neves Cavalcante Aline de Almeida Simões Manuella de Souza Sampaio Almeida Maricy Almeida Viol Ferreira Lopes Roberto Luiz da Silva Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols International Journal of Hematology-Oncology and Stem Cell Research Acute Lymphoblastic Leukemia; Lymphoid cells; Relapsed leukemia |
| title | Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols |
| title_full | Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols |
| title_fullStr | Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols |
| title_full_unstemmed | Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols |
| title_short | Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols |
| title_sort | treatment of acute lymphoid leukemia refractory to classic first line and rescue protocols |
| topic | Acute Lymphoblastic Leukemia; Lymphoid cells; Relapsed leukemia |
| url | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1161 |
| work_keys_str_mv | AT flaviatobaldinirusso treatmentofacutelymphoidleukemiarefractorytoclassicfirstlineandrescueprotocols AT mariacristinamartinsdealmeidamacedo treatmentofacutelymphoidleukemiarefractorytoclassicfirstlineandrescueprotocols AT pedroamoedofernandes treatmentofacutelymphoidleukemiarefractorytoclassicfirstlineandrescueprotocols AT larissayukariokada treatmentofacutelymphoidleukemiarefractorytoclassicfirstlineandrescueprotocols AT lucasaugustomonettadasilva treatmentofacutelymphoidleukemiarefractorytoclassicfirstlineandrescueprotocols AT camilameninsimoes treatmentofacutelymphoidleukemiarefractorytoclassicfirstlineandrescueprotocols AT jamillanevescavalcante treatmentofacutelymphoidleukemiarefractorytoclassicfirstlineandrescueprotocols AT alinedealmeidasimoes treatmentofacutelymphoidleukemiarefractorytoclassicfirstlineandrescueprotocols AT manuelladesouzasampaioalmeida treatmentofacutelymphoidleukemiarefractorytoclassicfirstlineandrescueprotocols AT maricyalmeidaviolferreiralopes treatmentofacutelymphoidleukemiarefractorytoclassicfirstlineandrescueprotocols AT robertoluizdasilva treatmentofacutelymphoidleukemiarefractorytoclassicfirstlineandrescueprotocols |