Novel Dihydroorotate Dehydrogenase Inhibitors with Potent Interferon-Independent Antiviral Activity against Mammarenaviruses In Vitro

Novel Dihydroorotate Dehydrogenase Inhibitors with Potent Interferon-Independent Antiviral Activity against Mammarenaviruses In Vitro

Mammarenaviruses cause chronic infections in rodents, which are their predominant natural hosts. Human infection with some of these viruses causes high-consequence disease, posing significant issues in public health. Currently, no FDA-licensed mammarenavirus vaccines are available, and anti-mammaren...

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Bibliographic Details
Main Authors: Yu-Jin Kim, Beatrice Cubitt, Yingyun Cai, Jens H. Kuhn, Daniel Vitt, Hella Kohlhof, Juan C. de la Torre
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Viruses
Subjects:
mammarenavirus
DHODH
pyrimidine biosynthesis
interferon
antiviral
Online Access:https://www.mdpi.com/1999-4915/12/8/821

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