Indoloquinoline-Mediated Targeted Downregulation of KRAS through Selective Stabilization of the Mid-Promoter G-Quadruplex Structure

Indoloquinoline-Mediated Targeted Downregulation of KRAS through Selective Stabilization of the Mid-Promoter G-Quadruplex Structure

KRAS is a well-validated anti-cancer therapeutic target, whose transcriptional downregulation has been demonstrated to be lethal to tumor cells with aberrant KRAS signaling. G-quadruplexes (G4s) are non-canonical nucleic acid structures that mediate central dogmatic events, such as DNA repair, telom...

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Bibliographic Details
Main Authors: Alexandra Maria Psaras, Rhianna K. Carty, Jared T. Miller, L. Nathan Tumey, Tracy A. Brooks
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Genes
Subjects:
KRAS
G-quadruplex
indoloquinolines
pancreatic cancer
Online Access:https://www.mdpi.com/2073-4425/13/8/1440

Internet

https://www.mdpi.com/2073-4425/13/8/1440

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