Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice

Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice

The outcome of an encounter with Mycobacterium tuberculosis (Mtb) depends on the pathogen’s ability to adapt to the variable immune pressures exerted by the host. Understanding this interplay has proven difficult, largely because experimentally tractable animal models do not recapitulate the heterog...

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Bibliographic Details
Main Authors: Clare M Smith, Richard E Baker, Megan K Proulx, Bibhuti B Mishra, Jarukit E Long, Sae Woong Park, Ha-Na Lee, Michael C Kiritsy, Michelle M Bellerose, Andrew J Olive, Kenan C Murphy, Kadamba Papavinasasundaram, Frederick J Boehm, Charlotte J Reames, Rachel K Meade, Brea K Hampton, Colton L Linnertz, Ginger D Shaw, Pablo Hock, Timothy A Bell, Sabine Ehrt, Dirk Schnappinger, Fernando Pardo-Manuel de Villena, Martin T Ferris, Thomas R Ioerger, Christopher M Sassetti
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-02-01
Series:eLife
Subjects:
host-pathogen interactions
tuberculosis
systems genetics
mouse models
collaborative cross
TnSeq
Online Access:https://elifesciences.org/articles/74419

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