Estimating risks and relative risks in case-base studies under the assumptions of gene-environment independence and Hardy-Weinberg equilibrium.
Many diseases result from the interactions between genes and the environment. An efficient method has been proposed for a case-control study to estimate the genetic and environmental main effects and their interactions, which exploits the assumptions of gene-environment independence and Hardy-Weinbe...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4138174?pdf=render |
| _version_ | 1818035426164736000 |
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| author | Tina Tsz-Ting Chui Wen-Chung Lee |
| author_facet | Tina Tsz-Ting Chui Wen-Chung Lee |
| author_sort | Tina Tsz-Ting Chui |
| collection | DOAJ |
| description | Many diseases result from the interactions between genes and the environment. An efficient method has been proposed for a case-control study to estimate the genetic and environmental main effects and their interactions, which exploits the assumptions of gene-environment independence and Hardy-Weinberg equilibrium. To estimate the absolute and relative risks, one needs to resort to an alternative design: the case-base study. In this paper, the authors show how to analyze a case-base study under the above dual assumptions. This approach is based on a conditional logistic regression of case-counterfactual controls matched data. It can be easily fitted with readily available statistical packages. When the dual assumptions are met, the method is approximately unbiased and has adequate coverage probabilities for confidence intervals. It also results in smaller variances and shorter confidence intervals as compared with a previous method for a case-base study which imposes neither assumption. |
| first_indexed | 2024-12-10T06:54:52Z |
| format | Article |
| id | doaj.art-22aa49cf266a4948b18b63c16e0e2dc8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T06:54:52Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-22aa49cf266a4948b18b63c16e0e2dc82022-12-22T01:58:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0198e10539810.1371/journal.pone.0105398Estimating risks and relative risks in case-base studies under the assumptions of gene-environment independence and Hardy-Weinberg equilibrium.Tina Tsz-Ting ChuiWen-Chung LeeMany diseases result from the interactions between genes and the environment. An efficient method has been proposed for a case-control study to estimate the genetic and environmental main effects and their interactions, which exploits the assumptions of gene-environment independence and Hardy-Weinberg equilibrium. To estimate the absolute and relative risks, one needs to resort to an alternative design: the case-base study. In this paper, the authors show how to analyze a case-base study under the above dual assumptions. This approach is based on a conditional logistic regression of case-counterfactual controls matched data. It can be easily fitted with readily available statistical packages. When the dual assumptions are met, the method is approximately unbiased and has adequate coverage probabilities for confidence intervals. It also results in smaller variances and shorter confidence intervals as compared with a previous method for a case-base study which imposes neither assumption.http://europepmc.org/articles/PMC4138174?pdf=render |
| spellingShingle | Tina Tsz-Ting Chui Wen-Chung Lee Estimating risks and relative risks in case-base studies under the assumptions of gene-environment independence and Hardy-Weinberg equilibrium. PLoS ONE |
| title | Estimating risks and relative risks in case-base studies under the assumptions of gene-environment independence and Hardy-Weinberg equilibrium. |
| title_full | Estimating risks and relative risks in case-base studies under the assumptions of gene-environment independence and Hardy-Weinberg equilibrium. |
| title_fullStr | Estimating risks and relative risks in case-base studies under the assumptions of gene-environment independence and Hardy-Weinberg equilibrium. |
| title_full_unstemmed | Estimating risks and relative risks in case-base studies under the assumptions of gene-environment independence and Hardy-Weinberg equilibrium. |
| title_short | Estimating risks and relative risks in case-base studies under the assumptions of gene-environment independence and Hardy-Weinberg equilibrium. |
| title_sort | estimating risks and relative risks in case base studies under the assumptions of gene environment independence and hardy weinberg equilibrium |
| url | http://europepmc.org/articles/PMC4138174?pdf=render |
| work_keys_str_mv | AT tinatsztingchui estimatingrisksandrelativerisksincasebasestudiesundertheassumptionsofgeneenvironmentindependenceandhardyweinbergequilibrium AT wenchunglee estimatingrisksandrelativerisksincasebasestudiesundertheassumptionsofgeneenvironmentindependenceandhardyweinbergequilibrium |