Pre- and Post-Zygotic TP53 De Novo Mutations in SHH-Medulloblastoma

Pre- and Post-Zygotic TP53 De Novo Mutations in SHH-Medulloblastoma

Li-Fraumeni syndrome (LFS) is an autosomal dominant disorder caused by mutations in the <i>TP53</i> gene, predisposing to a wide spectrum of early-onset cancers, including brain tumors. In medulloblastoma patients, the role of TP53 has been extensively investigated, though the prevalence...

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Bibliographic Details
Main Authors: Jacopo Azzollini, Elisabetta Schiavello, Francesca Romana Buttarelli, Carlo Alfredo Clerici, Laura Tizzoni, Giovanna De Vecchi, Fabio Capra, Federica Pisati, Veronica Biassoni, Letterio Runza, Giorgio Carrabba, Felice Giangaspero, Maura Massimino, Valeria Pensotti, Siranoush Manoukian
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
TP53
somatic mosaicism
medulloblastoma
de novo mutation
Li-Fraumeni syndrome
Online Access:https://www.mdpi.com/2072-6694/12/9/2503

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