5-((3-Amidobenzyl)oxy)nicotinamides as SIRT2 Inhibitors: A Study of Constrained Analogs

5-((3-Amidobenzyl)oxy)nicotinamides as SIRT2 Inhibitors: A Study of Constrained Analogs

SIRT2 is a member of NAD<sup>+</sup>-dependent sirtuins and its inhibition has been proposed as a promising therapeutic approach for treating human diseases, including neurodegenerative diseases, cancer, and infections. Expanding SIRT2 inhibitors based on the 3-aminobenzyloxy nicotinamid...

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Bibliographic Details
Main Authors: Teng Ai, Daniel J. Wilson, Liqiang Chen
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Molecules
Subjects:
sirtuins
sirtuin inhibitors
SIRT1
SIRT2
SIRT3
constrained inhibitors
Online Access:https://www.mdpi.com/1420-3049/28/22/7655

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