A novel papillomavirus in a New Zealand fur seal (Arctocephalus forsteri) with oral lesions
Abstract Despite being the predominant seal species in the Australian-New Zealand region and serving as a key indicator of marine environmental health, little is known about infectious diseases in New Zealand fur seals (Long-nosed fur seal; Arctocephalus forsteri). Several papillomaviruses have been...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-03-01
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| Series: | npj Viruses |
| Online Access: | https://doi.org/10.1038/s44298-024-00020-w |
| _version_ | 1797247385402867712 |
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| author | Jonathon C. O. Mifsud Jane Hall Kate Van Brussel Karrie Rose Rhys H. Parry Edward C. Holmes Erin Harvey |
| author_facet | Jonathon C. O. Mifsud Jane Hall Kate Van Brussel Karrie Rose Rhys H. Parry Edward C. Holmes Erin Harvey |
| author_sort | Jonathon C. O. Mifsud |
| collection | DOAJ |
| description | Abstract Despite being the predominant seal species in the Australian-New Zealand region and serving as a key indicator of marine environmental health, little is known about infectious diseases in New Zealand fur seals (Long-nosed fur seal; Arctocephalus forsteri). Several papillomaviruses have been identified in earless seals and sea lions, with the latter linked to cutaneous plaques and invasive squamous cell carcinoma. To date, no papillomaviruses have been reported in fur seals. We used traditional veterinary diagnostic techniques and metatranscriptomic sequencing of tissue samples to investigate the virome of New Zealand fur seals. We identified a novel papillomavirus, provisionally termed A. forsteri papillomavirus 1 (AforPV1) in an animal with clinically and histologically identified oral papilloma-like lesions. RT-PCR confirmed the presence of AforPV1 only in oral papilloma samples from the affected individual. Phylogenetic analysis of the complete 7926 bp genome of AforPV1 revealed that it grouped with taupapillomaviruses found in related Carnivora species. These findings highlight the need for further research into the disease associations and impact of undiagnosed and novel viruses on New Zealand fur seals. |
| first_indexed | 2024-04-24T19:57:51Z |
| format | Article |
| id | doaj.art-22b0c904821344f5a126cc3aed750cd3 |
| institution | Directory Open Access Journal |
| issn | 2948-1767 |
| language | English |
| last_indexed | 2024-04-24T19:57:51Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Viruses |
| spelling | doaj.art-22b0c904821344f5a126cc3aed750cd32024-03-24T12:12:42ZengNature Portfolionpj Viruses2948-17672024-03-01211810.1038/s44298-024-00020-wA novel papillomavirus in a New Zealand fur seal (Arctocephalus forsteri) with oral lesionsJonathon C. O. Mifsud0Jane Hall1Kate Van Brussel2Karrie Rose3Rhys H. Parry4Edward C. Holmes5Erin Harvey6Sydney Institute for Infectious Diseases, School of Medical Sciences, The University of SydneyCentre for Planetary Health and Food Security, School of Environment and Science, Griffith UniversitySydney Institute for Infectious Diseases, School of Medical Sciences, The University of SydneyAustralian Registry of Wildlife Health, Taronga Conservation Society AustraliaSchool of Chemistry and Molecular Biosciences, The University of QueenslandSydney Institute for Infectious Diseases, School of Medical Sciences, The University of SydneySydney Institute for Infectious Diseases, School of Medical Sciences, The University of SydneyAbstract Despite being the predominant seal species in the Australian-New Zealand region and serving as a key indicator of marine environmental health, little is known about infectious diseases in New Zealand fur seals (Long-nosed fur seal; Arctocephalus forsteri). Several papillomaviruses have been identified in earless seals and sea lions, with the latter linked to cutaneous plaques and invasive squamous cell carcinoma. To date, no papillomaviruses have been reported in fur seals. We used traditional veterinary diagnostic techniques and metatranscriptomic sequencing of tissue samples to investigate the virome of New Zealand fur seals. We identified a novel papillomavirus, provisionally termed A. forsteri papillomavirus 1 (AforPV1) in an animal with clinically and histologically identified oral papilloma-like lesions. RT-PCR confirmed the presence of AforPV1 only in oral papilloma samples from the affected individual. Phylogenetic analysis of the complete 7926 bp genome of AforPV1 revealed that it grouped with taupapillomaviruses found in related Carnivora species. These findings highlight the need for further research into the disease associations and impact of undiagnosed and novel viruses on New Zealand fur seals.https://doi.org/10.1038/s44298-024-00020-w |
| spellingShingle | Jonathon C. O. Mifsud Jane Hall Kate Van Brussel Karrie Rose Rhys H. Parry Edward C. Holmes Erin Harvey A novel papillomavirus in a New Zealand fur seal (Arctocephalus forsteri) with oral lesions npj Viruses |
| title | A novel papillomavirus in a New Zealand fur seal (Arctocephalus forsteri) with oral lesions |
| title_full | A novel papillomavirus in a New Zealand fur seal (Arctocephalus forsteri) with oral lesions |
| title_fullStr | A novel papillomavirus in a New Zealand fur seal (Arctocephalus forsteri) with oral lesions |
| title_full_unstemmed | A novel papillomavirus in a New Zealand fur seal (Arctocephalus forsteri) with oral lesions |
| title_short | A novel papillomavirus in a New Zealand fur seal (Arctocephalus forsteri) with oral lesions |
| title_sort | novel papillomavirus in a new zealand fur seal arctocephalus forsteri with oral lesions |
| url | https://doi.org/10.1038/s44298-024-00020-w |
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