First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus
Abstract Pulmonary mucormycosis (PM) is a rare, life‐threatening fungal infection usually affecting immunocompromised patients. Its incidence is rising, with a recent outbreak associated with COVID‐19 co‐infection. Amphotericin B along with early surgery are considered the standard treatment. Recurr...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-12-01
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| Series: | Respirology Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rcr2.877 |
| _version_ | 1818841026315419648 |
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| author | Cheuk Cheung Derek Leung Yu Hong Chan Man Ying Ho Ming Chiu Chan Chun Hoi Chen Chin Tong Kwok Yiu Cheong Yeung |
| author_facet | Cheuk Cheung Derek Leung Yu Hong Chan Man Ying Ho Ming Chiu Chan Chun Hoi Chen Chin Tong Kwok Yiu Cheong Yeung |
| author_sort | Cheuk Cheung Derek Leung |
| collection | DOAJ |
| description | Abstract Pulmonary mucormycosis (PM) is a rare, life‐threatening fungal infection usually affecting immunocompromised patients. Its incidence is rising, with a recent outbreak associated with COVID‐19 co‐infection. Amphotericin B along with early surgery are considered the standard treatment. Recurrence has been reported in patients without adequate treatment and without permanent reversal of predisposing factors. We report a case of late recurrence of PM in a renal transplant recipient. In 2012, he was diagnosed with PM. Imaging at the time showed a lingular mass. He was treated with antifungal for 1 year until complete radiological resolution. Surgical intervention was considered but no further follow‐up action was taken. In 2020, he presented with fever and haemoptysis. Imaging again showed a lingular mass, which was confirmed to be PM by bronchoscopic lung biopsy. This case highlights the importance of secondary antifungal prophylaxis for PM if permanent reversal of immunosuppression is not possible. |
| first_indexed | 2024-12-19T04:19:32Z |
| format | Article |
| id | doaj.art-22b1036d9b5540348bb5a5ece3e32856 |
| institution | Directory Open Access Journal |
| issn | 2051-3380 |
| language | English |
| last_indexed | 2024-12-19T04:19:32Z |
| publishDate | 2021-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Respirology Case Reports |
| spelling | doaj.art-22b1036d9b5540348bb5a5ece3e328562022-12-21T20:36:12ZengWileyRespirology Case Reports2051-33802021-12-01912n/an/a10.1002/rcr2.877First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitusCheuk Cheung Derek Leung0Yu Hong Chan1Man Ying Ho2Ming Chiu Chan3Chun Hoi Chen4Chin Tong Kwok5Yiu Cheong Yeung6Department of Medicine & Geriatrics Princess Margaret Hospital Hong KongDepartment of Medicine & Geriatrics Princess Margaret Hospital Hong KongDepartment of Medicine & Geriatrics Princess Margaret Hospital Hong KongDepartment of Medicine & Geriatrics Princess Margaret Hospital Hong KongDepartment of Medicine & Geriatrics Princess Margaret Hospital Hong KongDepartment of Medicine & Geriatrics Princess Margaret Hospital Hong KongDepartment of Medicine & Geriatrics Princess Margaret Hospital Hong KongAbstract Pulmonary mucormycosis (PM) is a rare, life‐threatening fungal infection usually affecting immunocompromised patients. Its incidence is rising, with a recent outbreak associated with COVID‐19 co‐infection. Amphotericin B along with early surgery are considered the standard treatment. Recurrence has been reported in patients without adequate treatment and without permanent reversal of predisposing factors. We report a case of late recurrence of PM in a renal transplant recipient. In 2012, he was diagnosed with PM. Imaging at the time showed a lingular mass. He was treated with antifungal for 1 year until complete radiological resolution. Surgical intervention was considered but no further follow‐up action was taken. In 2020, he presented with fever and haemoptysis. Imaging again showed a lingular mass, which was confirmed to be PM by bronchoscopic lung biopsy. This case highlights the importance of secondary antifungal prophylaxis for PM if permanent reversal of immunosuppression is not possible.https://doi.org/10.1002/rcr2.877diabetes mellituspulmonary mucormycosisrecurrencerenal transplantRhizopus |
| spellingShingle | Cheuk Cheung Derek Leung Yu Hong Chan Man Ying Ho Ming Chiu Chan Chun Hoi Chen Chin Tong Kwok Yiu Cheong Yeung First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus Respirology Case Reports diabetes mellitus pulmonary mucormycosis recurrence renal transplant Rhizopus |
| title | First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus |
| title_full | First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus |
| title_fullStr | First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus |
| title_full_unstemmed | First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus |
| title_short | First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus |
| title_sort | first reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus |
| topic | diabetes mellitus pulmonary mucormycosis recurrence renal transplant Rhizopus |
| url | https://doi.org/10.1002/rcr2.877 |
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