Hepatoblastoma—The Evolution of Biology, Surgery, and Transplantation
The most common primary malignant liver tumor of childhood, hepatoblastoma has increased in incidence over the last 30 years, but little is still known about its pathogenesis. Discoveries in molecular biology provide clues but have yet to define targeted therapies. Disease-free survival varies accor...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-12-01
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| Series: | Children |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2227-9067/6/1/1 |
| _version_ | 1818560496527212544 |
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| author | Irene Isabel P. Lim Alexander J. Bondoc James I. Geller Gregory M. Tiao |
| author_facet | Irene Isabel P. Lim Alexander J. Bondoc James I. Geller Gregory M. Tiao |
| author_sort | Irene Isabel P. Lim |
| collection | DOAJ |
| description | The most common primary malignant liver tumor of childhood, hepatoblastoma has increased in incidence over the last 30 years, but little is still known about its pathogenesis. Discoveries in molecular biology provide clues but have yet to define targeted therapies. Disease-free survival varies according to stage, but is greater than 90% in favorable risk populations, in part due to improvements in chemotherapeutic regimens, surgical resection, and earlier referral to liver transplant centers. This article aims to highlight the principles of disease that guide current treatment algorithms. Surgical treatment, especially orthotopic liver transplantation, will also be emphasized in the context of the current Children’s Oncology Group international study of pediatric liver cancer (AHEP-1531). |
| first_indexed | 2024-12-14T00:39:09Z |
| format | Article |
| id | doaj.art-22b131ef6ae74698863d8e8cc20278e2 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-12-14T00:39:09Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-22b131ef6ae74698863d8e8cc20278e22022-12-21T23:24:28ZengMDPI AGChildren2227-90672018-12-0161110.3390/children6010001children6010001Hepatoblastoma—The Evolution of Biology, Surgery, and TransplantationIrene Isabel P. Lim0Alexander J. Bondoc1James I. Geller2Gregory M. Tiao3Division of General and Thoracic Surgery, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USADivision of General and Thoracic Surgery, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USADivision of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USADivision of General and Thoracic Surgery, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USAThe most common primary malignant liver tumor of childhood, hepatoblastoma has increased in incidence over the last 30 years, but little is still known about its pathogenesis. Discoveries in molecular biology provide clues but have yet to define targeted therapies. Disease-free survival varies according to stage, but is greater than 90% in favorable risk populations, in part due to improvements in chemotherapeutic regimens, surgical resection, and earlier referral to liver transplant centers. This article aims to highlight the principles of disease that guide current treatment algorithms. Surgical treatment, especially orthotopic liver transplantation, will also be emphasized in the context of the current Children’s Oncology Group international study of pediatric liver cancer (AHEP-1531).http://www.mdpi.com/2227-9067/6/1/1hepatoblastomalivercancertransplant |
| spellingShingle | Irene Isabel P. Lim Alexander J. Bondoc James I. Geller Gregory M. Tiao Hepatoblastoma—The Evolution of Biology, Surgery, and Transplantation Children hepatoblastoma liver cancer transplant |
| title | Hepatoblastoma—The Evolution of Biology, Surgery, and Transplantation |
| title_full | Hepatoblastoma—The Evolution of Biology, Surgery, and Transplantation |
| title_fullStr | Hepatoblastoma—The Evolution of Biology, Surgery, and Transplantation |
| title_full_unstemmed | Hepatoblastoma—The Evolution of Biology, Surgery, and Transplantation |
| title_short | Hepatoblastoma—The Evolution of Biology, Surgery, and Transplantation |
| title_sort | hepatoblastoma the evolution of biology surgery and transplantation |
| topic | hepatoblastoma liver cancer transplant |
| url | http://www.mdpi.com/2227-9067/6/1/1 |
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