Medicinal plants and natural compounds against acyclovir-resistant HSV infections
Herpes simplex virus (HSV), an alphaherpesvirus, is highly prevalent in the human population and is known to cause oral and genital herpes and various complications. Represented by acyclovir (ACV), nucleoside analogs have been the main clinical treatment against HSV infection thus far. However, due...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.1025605/full |
| _version_ | 1828343883349622784 |
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| author | Lin Xu Lin Xu Xuan-Lei Zhong Xuan-Lei Zhong Zhi-Chao Xi Zhi-Chao Xi Yang Li Yang Li Hong-Xi Xu |
| author_facet | Lin Xu Lin Xu Xuan-Lei Zhong Xuan-Lei Zhong Zhi-Chao Xi Zhi-Chao Xi Yang Li Yang Li Hong-Xi Xu |
| author_sort | Lin Xu |
| collection | DOAJ |
| description | Herpes simplex virus (HSV), an alphaherpesvirus, is highly prevalent in the human population and is known to cause oral and genital herpes and various complications. Represented by acyclovir (ACV), nucleoside analogs have been the main clinical treatment against HSV infection thus far. However, due to prolonged and excessive use, HSV has developed ACV-resistant strains. Therefore, effective treatment against ACV-resistant HSV strains is urgently needed. In this review, we summarized the plant extracts and natural compounds that inhibited ACV-resistant HSV infection and their mechanism of action. |
| first_indexed | 2024-04-13T23:48:44Z |
| format | Article |
| id | doaj.art-22b1553710514784b7a7e0bd513762ba |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-13T23:48:44Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-22b1553710514784b7a7e0bd513762ba2022-12-22T02:24:11ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-10-011310.3389/fmicb.2022.10256051025605Medicinal plants and natural compounds against acyclovir-resistant HSV infectionsLin Xu0Lin Xu1Xuan-Lei Zhong2Xuan-Lei Zhong3Zhi-Chao Xi4Zhi-Chao Xi5Yang Li6Yang Li7Hong-Xi Xu8School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaEngineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaEngineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaEngineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaEngineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, ChinaShuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaHerpes simplex virus (HSV), an alphaherpesvirus, is highly prevalent in the human population and is known to cause oral and genital herpes and various complications. Represented by acyclovir (ACV), nucleoside analogs have been the main clinical treatment against HSV infection thus far. However, due to prolonged and excessive use, HSV has developed ACV-resistant strains. Therefore, effective treatment against ACV-resistant HSV strains is urgently needed. In this review, we summarized the plant extracts and natural compounds that inhibited ACV-resistant HSV infection and their mechanism of action.https://www.frontiersin.org/articles/10.3389/fmicb.2022.1025605/fullherpes simplex virusantiviral herbsnatural productsacyclovir-resistantmode of action |
| spellingShingle | Lin Xu Lin Xu Xuan-Lei Zhong Xuan-Lei Zhong Zhi-Chao Xi Zhi-Chao Xi Yang Li Yang Li Hong-Xi Xu Medicinal plants and natural compounds against acyclovir-resistant HSV infections Frontiers in Microbiology herpes simplex virus antiviral herbs natural products acyclovir-resistant mode of action |
| title | Medicinal plants and natural compounds against acyclovir-resistant HSV infections |
| title_full | Medicinal plants and natural compounds against acyclovir-resistant HSV infections |
| title_fullStr | Medicinal plants and natural compounds against acyclovir-resistant HSV infections |
| title_full_unstemmed | Medicinal plants and natural compounds against acyclovir-resistant HSV infections |
| title_short | Medicinal plants and natural compounds against acyclovir-resistant HSV infections |
| title_sort | medicinal plants and natural compounds against acyclovir resistant hsv infections |
| topic | herpes simplex virus antiviral herbs natural products acyclovir-resistant mode of action |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.1025605/full |
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