The Impact of Stem/Progenitor Cells on Lymphangiogenesis in Vascular Disease
Lymphatic vessels, as the main tube network of fluid drainage and leukocyte transfer, are responsible for the maintenance of homeostasis and pathological repairment. Recently, by using genetic lineage tracing and single-cell RNA sequencing techniques, significant cognitive progress has been made abo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/24/4056 |
| _version_ | 1797460923532705792 |
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| author | Rong Mou Kai Chen Pengwei Zhu Qingbo Xu Liang Ma |
| author_facet | Rong Mou Kai Chen Pengwei Zhu Qingbo Xu Liang Ma |
| author_sort | Rong Mou |
| collection | DOAJ |
| description | Lymphatic vessels, as the main tube network of fluid drainage and leukocyte transfer, are responsible for the maintenance of homeostasis and pathological repairment. Recently, by using genetic lineage tracing and single-cell RNA sequencing techniques, significant cognitive progress has been made about the impact of stem/progenitor cells during lymphangiogenesis. In the embryonic stage, the lymphatic network is primarily formed through self-proliferation and polarized-sprouting from the lymph sacs. However, the assembly of lymphatic stem/progenitor cells also guarantees the sustained growth of lymphvasculogenesis to obtain the entire function. In addition, there are abundant sources of stem/progenitor cells in postnatal tissues, including circulating progenitors, mesenchymal stem cells, and adipose tissue stem cells, which can directly differentiate into lymphatic endothelial cells and participate in lymphangiogenesis. Specifically, recent reports indicated a novel function of lymphangiogenesis in transplant arteriosclerosis and atherosclerosis. In the present review, we summarized the latest evidence about the diversity and incorporation of stem/progenitor cells in lymphatic vasculature during both the embryonic and postnatal stages, with emphasis on the impact of lymphangiogenesis in the development of vascular diseases to provide a rational guidance for future research. |
| first_indexed | 2024-03-09T17:12:04Z |
| format | Article |
| id | doaj.art-22b1ce3747c949d58404563f5b5c5853 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T17:12:04Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-22b1ce3747c949d58404563f5b5c58532023-11-24T13:55:04ZengMDPI AGCells2073-44092022-12-011124405610.3390/cells11244056The Impact of Stem/Progenitor Cells on Lymphangiogenesis in Vascular DiseaseRong Mou0Kai Chen1Pengwei Zhu2Qingbo Xu3Liang Ma4Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaDepartment of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaDepartment of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaDepartment of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaDepartment of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaLymphatic vessels, as the main tube network of fluid drainage and leukocyte transfer, are responsible for the maintenance of homeostasis and pathological repairment. Recently, by using genetic lineage tracing and single-cell RNA sequencing techniques, significant cognitive progress has been made about the impact of stem/progenitor cells during lymphangiogenesis. In the embryonic stage, the lymphatic network is primarily formed through self-proliferation and polarized-sprouting from the lymph sacs. However, the assembly of lymphatic stem/progenitor cells also guarantees the sustained growth of lymphvasculogenesis to obtain the entire function. In addition, there are abundant sources of stem/progenitor cells in postnatal tissues, including circulating progenitors, mesenchymal stem cells, and adipose tissue stem cells, which can directly differentiate into lymphatic endothelial cells and participate in lymphangiogenesis. Specifically, recent reports indicated a novel function of lymphangiogenesis in transplant arteriosclerosis and atherosclerosis. In the present review, we summarized the latest evidence about the diversity and incorporation of stem/progenitor cells in lymphatic vasculature during both the embryonic and postnatal stages, with emphasis on the impact of lymphangiogenesis in the development of vascular diseases to provide a rational guidance for future research.https://www.mdpi.com/2073-4409/11/24/4056stem cellsprogenitorslymphangiogenesislymphavasculogenesisarteriosclerosis |
| spellingShingle | Rong Mou Kai Chen Pengwei Zhu Qingbo Xu Liang Ma The Impact of Stem/Progenitor Cells on Lymphangiogenesis in Vascular Disease Cells stem cells progenitors lymphangiogenesis lymphavasculogenesis arteriosclerosis |
| title | The Impact of Stem/Progenitor Cells on Lymphangiogenesis in Vascular Disease |
| title_full | The Impact of Stem/Progenitor Cells on Lymphangiogenesis in Vascular Disease |
| title_fullStr | The Impact of Stem/Progenitor Cells on Lymphangiogenesis in Vascular Disease |
| title_full_unstemmed | The Impact of Stem/Progenitor Cells on Lymphangiogenesis in Vascular Disease |
| title_short | The Impact of Stem/Progenitor Cells on Lymphangiogenesis in Vascular Disease |
| title_sort | impact of stem progenitor cells on lymphangiogenesis in vascular disease |
| topic | stem cells progenitors lymphangiogenesis lymphavasculogenesis arteriosclerosis |
| url | https://www.mdpi.com/2073-4409/11/24/4056 |
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