Mechanical ventilation drives inflammation in severe viral bronchiolitis.
INTRODUCTION: Respiratory insufficiency due to severe respiratory syncytial virus (RSV) infection is the most frequent cause of paediatric intensive care unit admission in infants during the winter season. Previous studies have shown increased levels of inflammatory mediators in airways of mechanica...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3859624?pdf=render |
| _version_ | 1819265762990227456 |
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| author | Marije P Hennus Adrianus J van Vught Mark Brabander Frank Brus Nicolaas J Jansen Louis J Bont |
| author_facet | Marije P Hennus Adrianus J van Vught Mark Brabander Frank Brus Nicolaas J Jansen Louis J Bont |
| author_sort | Marije P Hennus |
| collection | DOAJ |
| description | INTRODUCTION: Respiratory insufficiency due to severe respiratory syncytial virus (RSV) infection is the most frequent cause of paediatric intensive care unit admission in infants during the winter season. Previous studies have shown increased levels of inflammatory mediators in airways of mechanically ventilated children compared to spontaneous breathing children with viral bronchiolitis. In this prospective observational multi-center study we aimed to investigate whether this increase was related to disease severity or caused by mechanical ventilation. MATERIALS AND METHODS: Nasopharyngeal aspirates were collected <1 hour before intubation and 24 hours later in RSV bronchiolitis patients with respiratory failure (n = 18) and non-ventilated RSV bronchiolitis controls (n = 18). Concentrations of the following cytokines were measured: interleukin (IL)-1α, IL-1β, IL-6, monocyte chemotactic protein (MCP)-1 and macrophage inflammatory protein (MIP)-1α. RESULTS: Baseline cytokine levels were comparable between ventilated and non-ventilated infants. After 24 hours of mechanical ventilation mean cytokine levels, except for MIP-1α, were elevated compared to non-ventilated infected controls: IL-1α (159 versus 4 pg/ml, p<0.01), IL-1β (1068 versus 99 pg/ml, p<0.01), IL-6 (2343 versus 958 pg/ml, p<0.05) and MCP-1 (174 versus 26 pg/ml, p<0.05). CONCLUSIONS: Using pre- and post-intubation observations, this study suggests that endotracheal intubation and subsequent mechanical ventilation cause a robust pulmonary inflammation in infants with RSV bronchiolitis. |
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| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T20:50:32Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-22b2df131fc04824bcd5ac3dd6347ee62022-12-21T17:31:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01812e8303510.1371/journal.pone.0083035Mechanical ventilation drives inflammation in severe viral bronchiolitis.Marije P HennusAdrianus J van VughtMark BrabanderFrank BrusNicolaas J JansenLouis J BontINTRODUCTION: Respiratory insufficiency due to severe respiratory syncytial virus (RSV) infection is the most frequent cause of paediatric intensive care unit admission in infants during the winter season. Previous studies have shown increased levels of inflammatory mediators in airways of mechanically ventilated children compared to spontaneous breathing children with viral bronchiolitis. In this prospective observational multi-center study we aimed to investigate whether this increase was related to disease severity or caused by mechanical ventilation. MATERIALS AND METHODS: Nasopharyngeal aspirates were collected <1 hour before intubation and 24 hours later in RSV bronchiolitis patients with respiratory failure (n = 18) and non-ventilated RSV bronchiolitis controls (n = 18). Concentrations of the following cytokines were measured: interleukin (IL)-1α, IL-1β, IL-6, monocyte chemotactic protein (MCP)-1 and macrophage inflammatory protein (MIP)-1α. RESULTS: Baseline cytokine levels were comparable between ventilated and non-ventilated infants. After 24 hours of mechanical ventilation mean cytokine levels, except for MIP-1α, were elevated compared to non-ventilated infected controls: IL-1α (159 versus 4 pg/ml, p<0.01), IL-1β (1068 versus 99 pg/ml, p<0.01), IL-6 (2343 versus 958 pg/ml, p<0.05) and MCP-1 (174 versus 26 pg/ml, p<0.05). CONCLUSIONS: Using pre- and post-intubation observations, this study suggests that endotracheal intubation and subsequent mechanical ventilation cause a robust pulmonary inflammation in infants with RSV bronchiolitis.http://europepmc.org/articles/PMC3859624?pdf=render |
| spellingShingle | Marije P Hennus Adrianus J van Vught Mark Brabander Frank Brus Nicolaas J Jansen Louis J Bont Mechanical ventilation drives inflammation in severe viral bronchiolitis. PLoS ONE |
| title | Mechanical ventilation drives inflammation in severe viral bronchiolitis. |
| title_full | Mechanical ventilation drives inflammation in severe viral bronchiolitis. |
| title_fullStr | Mechanical ventilation drives inflammation in severe viral bronchiolitis. |
| title_full_unstemmed | Mechanical ventilation drives inflammation in severe viral bronchiolitis. |
| title_short | Mechanical ventilation drives inflammation in severe viral bronchiolitis. |
| title_sort | mechanical ventilation drives inflammation in severe viral bronchiolitis |
| url | http://europepmc.org/articles/PMC3859624?pdf=render |
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