Neurological complications of diabetes mellitus
Diabetes mellitus (DM) seriously and negatively affects the physical, mental and social well-being of patients. Among the complications of DM, neurological complications associated with both central and peripheral nervous system lesions are of great importance to the patient’s health. These include...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Remedium Group LLC
2019-06-01
|
| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/3033 |
| _version_ | 1827962402522529792 |
|---|---|
| author | O. V. Kotova E. S. Akarachkova A. A. Belyaev |
| author_facet | O. V. Kotova E. S. Akarachkova A. A. Belyaev |
| author_sort | O. V. Kotova |
| collection | DOAJ |
| description | Diabetes mellitus (DM) seriously and negatively affects the physical, mental and social well-being of patients. Among the complications of DM, neurological complications associated with both central and peripheral nervous system lesions are of great importance to the patient’s health. These include reduced cognitive function and neuropathy. A decrease in cognitive function associated with DM is observed in both patients with DM 1 and 2 types. There is a connection between the presence of diabetic retinopathy at baseline and changes in cognitive function over time in patients with DM2. Initial diabetic retinopathy and the severity of retinopathy are associated with a decrease in all cognitive functions and a decrease in the rate of information processing. The pathogenesis of diabetic polyneuropathy (DPN) is determined by metabolic disturbances in nerve and epithelial cells, which occur due to hyperglycemia and lead to impaired function of microcirculatory vessels and peripheral nerve fibers. Pathogenetic treatment of DPN is based on modern ideas about the mechanisms of its occurrence and progression. In particular, preparations with antioxidant effect are used, among which the efficacy of alpha-lipoic (thioctic) acid (ALA) in DPN is well proven, and one of such preparations is Berlithion («Berlin-Chemie», Germany). Among other effective drugs used in the treatment of neurological complications of DM, dipyridamole (Curantyl) is used, as the drug affects microangiopathy associated with DM. |
| first_indexed | 2024-04-09T16:42:02Z |
| format | Article |
| id | doaj.art-22b3f98679494ee894966002b393bda9 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:42:02Z |
| publishDate | 2019-06-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-22b3f98679494ee894966002b393bda92023-04-23T06:56:38ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902019-06-0109404410.21518/2079-701X-2019-9-40-442948Neurological complications of diabetes mellitusO. V. Kotova0E. S. Akarachkova1A. A. Belyaev2International Society «Stress under Control».International Society «Stress under Control».State Budgetary Healthcare Institution of the City of Moscow «Research Institute of Emergency Medical Care named after N.V. Sklifosovsky of the Department of Healthcare of Moscow».Diabetes mellitus (DM) seriously and negatively affects the physical, mental and social well-being of patients. Among the complications of DM, neurological complications associated with both central and peripheral nervous system lesions are of great importance to the patient’s health. These include reduced cognitive function and neuropathy. A decrease in cognitive function associated with DM is observed in both patients with DM 1 and 2 types. There is a connection between the presence of diabetic retinopathy at baseline and changes in cognitive function over time in patients with DM2. Initial diabetic retinopathy and the severity of retinopathy are associated with a decrease in all cognitive functions and a decrease in the rate of information processing. The pathogenesis of diabetic polyneuropathy (DPN) is determined by metabolic disturbances in nerve and epithelial cells, which occur due to hyperglycemia and lead to impaired function of microcirculatory vessels and peripheral nerve fibers. Pathogenetic treatment of DPN is based on modern ideas about the mechanisms of its occurrence and progression. In particular, preparations with antioxidant effect are used, among which the efficacy of alpha-lipoic (thioctic) acid (ALA) in DPN is well proven, and one of such preparations is Berlithion («Berlin-Chemie», Germany). Among other effective drugs used in the treatment of neurological complications of DM, dipyridamole (Curantyl) is used, as the drug affects microangiopathy associated with DM.https://www.med-sovet.pro/jour/article/view/3033diabetes mellitus, cognitive functions, neuropathy, alpha-lipoic acid, dipyridamol |
| spellingShingle | O. V. Kotova E. S. Akarachkova A. A. Belyaev Neurological complications of diabetes mellitus Медицинский совет diabetes mellitus, cognitive functions, neuropathy, alpha-lipoic acid, dipyridamol |
| title | Neurological complications of diabetes mellitus |
| title_full | Neurological complications of diabetes mellitus |
| title_fullStr | Neurological complications of diabetes mellitus |
| title_full_unstemmed | Neurological complications of diabetes mellitus |
| title_short | Neurological complications of diabetes mellitus |
| title_sort | neurological complications of diabetes mellitus |
| topic | diabetes mellitus, cognitive functions, neuropathy, alpha-lipoic acid, dipyridamol |
| url | https://www.med-sovet.pro/jour/article/view/3033 |
| work_keys_str_mv | AT ovkotova neurologicalcomplicationsofdiabetesmellitus AT esakarachkova neurologicalcomplicationsofdiabetesmellitus AT aabelyaev neurologicalcomplicationsofdiabetesmellitus |