Blood flow in the anterior humeral circumflex artery reflects synovial inflammation of the shoulder joint in rotator cuff tears
Background: An association has been reported between rotator cuff tear and inflammation. We hypothesized that blood flow in the anterior humeral circumflex artery would reflect synovial inflammation in the shoulder. This study aimed to clarify the association of blood flow in the anterior humeral ci...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | JSES International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666638322000998 |
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| author | Hiromi Asano, MD Nobuo Terabayashi, MD, PhD Kenji Kawashima, MD, PhD Atsushi Goto, MD Tsuneo Watanabe, PhD Takuma Ishihara, MSc Haruhiko Akiyama, MD, PhD |
| author_facet | Hiromi Asano, MD Nobuo Terabayashi, MD, PhD Kenji Kawashima, MD, PhD Atsushi Goto, MD Tsuneo Watanabe, PhD Takuma Ishihara, MSc Haruhiko Akiyama, MD, PhD |
| author_sort | Hiromi Asano, MD |
| collection | DOAJ |
| description | Background: An association has been reported between rotator cuff tear and inflammation. We hypothesized that blood flow in the anterior humeral circumflex artery would reflect synovial inflammation in the shoulder. This study aimed to clarify the association of blood flow in the anterior humeral circumflex artery with synovial inflammation and shoulder pain in patients with rotator cuff tears. Methods: In this prospective, cross-sectional study, tissue samples from the synovium in the rotator interval were obtained from 33 patients undergoing arthroscopic rotator cuff repair. Reverse transcription-polymerase chain reaction and real-time polymerase chain reaction were performed to determine the messenger RNA expression of inflammatory mediators, growth factors, and matrix metalloproteinases. Additional tissue samples were fixed for histologic evaluation. Before surgery, we measured the peak systolic velocity in the anterior humeral circumflex artery using pulse Doppler ultrasonography. Results: The peak systolic velocity in the anterior humeral circumflex artery was positively correlated with the messenger RNA expression of interleukin 1β, interleukin 8, and matrix metalloproteinase 3 genes (r = 0.49, P = .004; r = 0.55, P = .001; and r = 0.39, P = .026, respectively), as well as histologic synovitis scores (r = 0.48, P = .005). Additionally, it was significantly higher in patients with resting pain than in those without resting pain (P = .048). Conclusion: The peak systolic velocity in the anterior humeral circumflex artery is associated with the severity of synovial inflammation. Our results suggest that assessing the peak systolic velocity in the anterior humeral circumflex artery is useful for evaluating the severity of synovial inflammation. |
| first_indexed | 2024-12-12T13:25:41Z |
| format | Article |
| id | doaj.art-22b430fda68349a38b73af05099b67c6 |
| institution | Directory Open Access Journal |
| issn | 2666-6383 |
| language | English |
| last_indexed | 2024-12-12T13:25:41Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JSES International |
| spelling | doaj.art-22b430fda68349a38b73af05099b67c62022-12-22T00:23:11ZengElsevierJSES International2666-63832022-07-0164623630Blood flow in the anterior humeral circumflex artery reflects synovial inflammation of the shoulder joint in rotator cuff tearsHiromi Asano, MD0Nobuo Terabayashi, MD, PhD1Kenji Kawashima, MD, PhD2Atsushi Goto, MD3Tsuneo Watanabe, PhD4Takuma Ishihara, MSc5Haruhiko Akiyama, MD, PhD6Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine, Gifu, JapanDepartment of Orthopaedic Surgery, Gifu University Graduate School of Medicine, Gifu, Japan; Corresponding author: Nobuo Terabayashi, MD, PhD, Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu city, Gifu 501-1194, Japan.Department of Orthopaedic Surgery, Yamauchi Hospital, Gifu, JapanDepartment of Orthopaedic Surgery, Gifu University Graduate School of Medicine, Gifu, JapanDepartment of Medical Technology, Gifu University of Medical Science, Gifu, JapanInnovative and Clinical Research Promotion Center, Gifu University Hospital, Gifu, JapanDepartment of Orthopaedic Surgery, Gifu University Graduate School of Medicine, Gifu, JapanBackground: An association has been reported between rotator cuff tear and inflammation. We hypothesized that blood flow in the anterior humeral circumflex artery would reflect synovial inflammation in the shoulder. This study aimed to clarify the association of blood flow in the anterior humeral circumflex artery with synovial inflammation and shoulder pain in patients with rotator cuff tears. Methods: In this prospective, cross-sectional study, tissue samples from the synovium in the rotator interval were obtained from 33 patients undergoing arthroscopic rotator cuff repair. Reverse transcription-polymerase chain reaction and real-time polymerase chain reaction were performed to determine the messenger RNA expression of inflammatory mediators, growth factors, and matrix metalloproteinases. Additional tissue samples were fixed for histologic evaluation. Before surgery, we measured the peak systolic velocity in the anterior humeral circumflex artery using pulse Doppler ultrasonography. Results: The peak systolic velocity in the anterior humeral circumflex artery was positively correlated with the messenger RNA expression of interleukin 1β, interleukin 8, and matrix metalloproteinase 3 genes (r = 0.49, P = .004; r = 0.55, P = .001; and r = 0.39, P = .026, respectively), as well as histologic synovitis scores (r = 0.48, P = .005). Additionally, it was significantly higher in patients with resting pain than in those without resting pain (P = .048). Conclusion: The peak systolic velocity in the anterior humeral circumflex artery is associated with the severity of synovial inflammation. Our results suggest that assessing the peak systolic velocity in the anterior humeral circumflex artery is useful for evaluating the severity of synovial inflammation.http://www.sciencedirect.com/science/article/pii/S2666638322000998Rotator cuff tearSynovial inflammationPulse Doppler ultrasonographyBlood flowPeak systolic velocityAnterior humeral circumflex artery |
| spellingShingle | Hiromi Asano, MD Nobuo Terabayashi, MD, PhD Kenji Kawashima, MD, PhD Atsushi Goto, MD Tsuneo Watanabe, PhD Takuma Ishihara, MSc Haruhiko Akiyama, MD, PhD Blood flow in the anterior humeral circumflex artery reflects synovial inflammation of the shoulder joint in rotator cuff tears JSES International Rotator cuff tear Synovial inflammation Pulse Doppler ultrasonography Blood flow Peak systolic velocity Anterior humeral circumflex artery |
| title | Blood flow in the anterior humeral circumflex artery reflects synovial inflammation of the shoulder joint in rotator cuff tears |
| title_full | Blood flow in the anterior humeral circumflex artery reflects synovial inflammation of the shoulder joint in rotator cuff tears |
| title_fullStr | Blood flow in the anterior humeral circumflex artery reflects synovial inflammation of the shoulder joint in rotator cuff tears |
| title_full_unstemmed | Blood flow in the anterior humeral circumflex artery reflects synovial inflammation of the shoulder joint in rotator cuff tears |
| title_short | Blood flow in the anterior humeral circumflex artery reflects synovial inflammation of the shoulder joint in rotator cuff tears |
| title_sort | blood flow in the anterior humeral circumflex artery reflects synovial inflammation of the shoulder joint in rotator cuff tears |
| topic | Rotator cuff tear Synovial inflammation Pulse Doppler ultrasonography Blood flow Peak systolic velocity Anterior humeral circumflex artery |
| url | http://www.sciencedirect.com/science/article/pii/S2666638322000998 |
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