Dysgerminoma in Pseudohermaphroditism: A Case Report
Female pseudohermaphroditism occurs when normal ovaries are present but the body is partially masculinized as individuals with congenital adrenal hyperplasia, also known as adrenogenital syndrome. This is an inherited disorder that accounts for about one-half of all cases of human intersexuality. We...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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HEAD Nepal
2020-12-01
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| Series: | Nepalese Medical Journal |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/nmj/article/view/34909 |
| _version_ | 1818884521310814208 |
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| author | Rashmey Pun Sujata Pudasaini Rita Mahaseth Kriti Shrestha |
| author_facet | Rashmey Pun Sujata Pudasaini Rita Mahaseth Kriti Shrestha |
| author_sort | Rashmey Pun |
| collection | DOAJ |
| description | Female pseudohermaphroditism occurs when normal ovaries are present but the body is partially masculinized as individuals with congenital adrenal hyperplasia, also known as adrenogenital syndrome. This is an inherited disorder that accounts for about one-half of all cases of human intersexuality. We report a case of a 24-year-old male presenting with abdominal pain and increasing abdominal distension for one month. Computed tomography scan revealed large multiloculated heterogeneously enhancing solid –cystic lesion in the abdominopelvic cavity– malignant gonadal mass, gross ascites, and visualization of the poorly formed elongated uterus-like structure in the recto-uterine pouch and phallus-like structure with non-visualization of bilateral testes. Histopathology report suggested germ cell tumor and immunohistochemistry confirmed the diagnosis of dysgerminoma. Since dysgerminoma is sensitive to platinum-based chemotherapy patient was subjected to chemotherapy and the patient showed a good response. The patient underwent exploratory laparotomy with right salpingo-oophorectomy with omentectomy and appendectomy. |
| first_indexed | 2024-12-19T15:50:52Z |
| format | Article |
| id | doaj.art-22b59876e3244be4a175991307500640 |
| institution | Directory Open Access Journal |
| issn | 2631-2093 2645-8586 |
| language | English |
| last_indexed | 2024-12-19T15:50:52Z |
| publishDate | 2020-12-01 |
| publisher | HEAD Nepal |
| record_format | Article |
| series | Nepalese Medical Journal |
| spelling | doaj.art-22b59876e3244be4a1759913075006402022-12-21T20:15:12ZengHEAD NepalNepalese Medical Journal2631-20932645-85862020-12-013238438710.3126/nmj.v3i2.3490934909Dysgerminoma in Pseudohermaphroditism: A Case ReportRashmey Pun0Sujata Pudasaini1Rita Mahaseth2Kriti Shrestha3Nepal Medical College Teaching Hospital Attarkhel, Kathmandu, NepalNepal Medical College Teaching Hospital, Kathmandu, NepalNepal Medical College Teaching Hospital, Kathmandu, NepalNepal Medical College Teaching Hospital, Kathmandu, NepalFemale pseudohermaphroditism occurs when normal ovaries are present but the body is partially masculinized as individuals with congenital adrenal hyperplasia, also known as adrenogenital syndrome. This is an inherited disorder that accounts for about one-half of all cases of human intersexuality. We report a case of a 24-year-old male presenting with abdominal pain and increasing abdominal distension for one month. Computed tomography scan revealed large multiloculated heterogeneously enhancing solid –cystic lesion in the abdominopelvic cavity– malignant gonadal mass, gross ascites, and visualization of the poorly formed elongated uterus-like structure in the recto-uterine pouch and phallus-like structure with non-visualization of bilateral testes. Histopathology report suggested germ cell tumor and immunohistochemistry confirmed the diagnosis of dysgerminoma. Since dysgerminoma is sensitive to platinum-based chemotherapy patient was subjected to chemotherapy and the patient showed a good response. The patient underwent exploratory laparotomy with right salpingo-oophorectomy with omentectomy and appendectomy.https://www.nepjol.info/index.php/nmj/article/view/34909dysgerminoma; gonadal dysgenesis; karyotyping; pseudohermaphroditism |
| spellingShingle | Rashmey Pun Sujata Pudasaini Rita Mahaseth Kriti Shrestha Dysgerminoma in Pseudohermaphroditism: A Case Report Nepalese Medical Journal dysgerminoma; gonadal dysgenesis; karyotyping; pseudohermaphroditism |
| title | Dysgerminoma in Pseudohermaphroditism: A Case Report |
| title_full | Dysgerminoma in Pseudohermaphroditism: A Case Report |
| title_fullStr | Dysgerminoma in Pseudohermaphroditism: A Case Report |
| title_full_unstemmed | Dysgerminoma in Pseudohermaphroditism: A Case Report |
| title_short | Dysgerminoma in Pseudohermaphroditism: A Case Report |
| title_sort | dysgerminoma in pseudohermaphroditism a case report |
| topic | dysgerminoma; gonadal dysgenesis; karyotyping; pseudohermaphroditism |
| url | https://www.nepjol.info/index.php/nmj/article/view/34909 |
| work_keys_str_mv | AT rashmeypun dysgerminomainpseudohermaphroditismacasereport AT sujatapudasaini dysgerminomainpseudohermaphroditismacasereport AT ritamahaseth dysgerminomainpseudohermaphroditismacasereport AT kritishrestha dysgerminomainpseudohermaphroditismacasereport |