Targeted expression profiling reveals distinct stages of early canine fibroblast reprogramming are regulated by 2-oxoglutarate hydroxylases

Targeted expression profiling reveals distinct stages of early canine fibroblast reprogramming are regulated by 2-oxoglutarate hydroxylases

Abstract Background Ectopic expression of a defined set of transcription factors allows the reprogramming of mammalian somatic cells to pluripotency. Despite continuous progress in primate and rodent reprogramming, limited attention has been paid to cell reprogramming in domestic and companion speci...

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Bibliographic Details
Main Authors: Ian C. Tobias, Mian-Mian C. Kao, Thomas Parmentier, Hailey Hunter, Jonathan LaMarre, Dean H. Betts
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Stem Cell Research & Therapy
Subjects:
Reprogramming
Pluripotent
Mesenchymal-to-epithelial transition
Canine
DNA hydroxymethylation
TET dioxygenase
Online Access:https://doi.org/10.1186/s13287-020-02047-1

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