Evaluation of menstrual irregularities after COVID-19 vaccination: Results of the MECOVAC survey
We investigated menstrual irregularities after the first and second doses of the COVID-19 vaccine. Women answered a customised online questionnaire (ClinicalTrial.gov ID: NCT05083065) aimed to assess the vaccine type, the phase of the menstrual cycle during which the vaccine was administered, the oc...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-03-01
|
| Series: | Open Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/med-2022-0452 |
| _version_ | 1797998353399676928 |
|---|---|
| author | Laganà Antonio Simone Veronesi Giovanni Ghezzi Fabio Ferrario Marco Mario Cromi Antonella Bizzarri Mariano Garzon Simone Cosentino Marco |
| author_facet | Laganà Antonio Simone Veronesi Giovanni Ghezzi Fabio Ferrario Marco Mario Cromi Antonella Bizzarri Mariano Garzon Simone Cosentino Marco |
| author_sort | Laganà Antonio Simone |
| collection | DOAJ |
| description | We investigated menstrual irregularities after the first and second doses of the COVID-19 vaccine. Women answered a customised online questionnaire (ClinicalTrial.gov ID: NCT05083065) aimed to assess the vaccine type, the phase of the menstrual cycle during which the vaccine was administered, the occurrence of menstrual irregularities after the first and second doses, and how long this effect lasted. We excluded women with gynaecological and non-gynaecological diseases, undergoing hormonal and non-hormonal treatments, in perimenopause or menopause, as well as those who had irregular menstrual cycles in the last 12 months before vaccine administration. According to our data analysis, approximately 50–60% of reproductive-age women who received the first dose of the COVID-19 vaccine reported menstrual cycle irregularities, regardless of the type of administered vaccine. The occurrence of menstrual irregularities seems to be slightly higher (60–70%) after the second dose. Menstrual irregularities after both the first and second doses of the vaccine were found to self-resolve in approximately half the cases within two months. Based on these results, we suggest to consider these elements during the counselling of women who receive the COVID-19 vaccine, letting them know about the potential occurrence of temporary and self-limiting menstrual cycle irregularities in the subsequent month(s). |
| first_indexed | 2024-04-11T10:47:21Z |
| format | Article |
| id | doaj.art-22b6aabdbb1e4a0a9641fdae7019e901 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-04-11T10:47:21Z |
| publishDate | 2022-03-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-22b6aabdbb1e4a0a9641fdae7019e9012022-12-22T04:29:00ZengDe GruyterOpen Medicine2391-54632022-03-0117147548410.1515/med-2022-0452Evaluation of menstrual irregularities after COVID-19 vaccination: Results of the MECOVAC surveyLaganà Antonio Simone0Veronesi Giovanni1Ghezzi Fabio2Ferrario Marco Mario3Cromi Antonella4Bizzarri Mariano5Garzon Simone6Cosentino Marco7Department of Obstetrics and Gynecology, “Filippo Del Ponte” Hospital, University of Insubria, 21100, Varese, ItalyDepartment of Medicine and Surgery, School of Medicine, Research Center in Epidemiology and Preventive Medicine, University of Insubria, 21100, Varese, ItalyDepartment of Obstetrics and Gynecology, “Filippo Del Ponte” Hospital, University of Insubria, 21100, Varese, ItalyDepartment of Medicine and Surgery, School of Medicine, Research Center in Epidemiology and Preventive Medicine, University of Insubria, 21100, Varese, ItalyDepartment of Obstetrics and Gynecology, “Filippo Del Ponte” Hospital, University of Insubria, 21100, Varese, ItalyDepartment of Experimental Medicine, Systems Biology Group Lab, University La Sapienza, 00161, Rome, ItalyDepartment of Obstetrics and Gynaecology, AOUI Verona, University of Verona, 37126, Verona, ItalyCenter for Research in Medical Pharmacology, University of Insubria, 21100, Varese, ItalyWe investigated menstrual irregularities after the first and second doses of the COVID-19 vaccine. Women answered a customised online questionnaire (ClinicalTrial.gov ID: NCT05083065) aimed to assess the vaccine type, the phase of the menstrual cycle during which the vaccine was administered, the occurrence of menstrual irregularities after the first and second doses, and how long this effect lasted. We excluded women with gynaecological and non-gynaecological diseases, undergoing hormonal and non-hormonal treatments, in perimenopause or menopause, as well as those who had irregular menstrual cycles in the last 12 months before vaccine administration. According to our data analysis, approximately 50–60% of reproductive-age women who received the first dose of the COVID-19 vaccine reported menstrual cycle irregularities, regardless of the type of administered vaccine. The occurrence of menstrual irregularities seems to be slightly higher (60–70%) after the second dose. Menstrual irregularities after both the first and second doses of the vaccine were found to self-resolve in approximately half the cases within two months. Based on these results, we suggest to consider these elements during the counselling of women who receive the COVID-19 vaccine, letting them know about the potential occurrence of temporary and self-limiting menstrual cycle irregularities in the subsequent month(s).https://doi.org/10.1515/med-2022-0452covid-19vaccinemenstrual irregularitiesabnormal uterine bleedingadverse effect |
| spellingShingle | Laganà Antonio Simone Veronesi Giovanni Ghezzi Fabio Ferrario Marco Mario Cromi Antonella Bizzarri Mariano Garzon Simone Cosentino Marco Evaluation of menstrual irregularities after COVID-19 vaccination: Results of the MECOVAC survey Open Medicine covid-19 vaccine menstrual irregularities abnormal uterine bleeding adverse effect |
| title | Evaluation of menstrual irregularities after COVID-19 vaccination: Results of the MECOVAC survey |
| title_full | Evaluation of menstrual irregularities after COVID-19 vaccination: Results of the MECOVAC survey |
| title_fullStr | Evaluation of menstrual irregularities after COVID-19 vaccination: Results of the MECOVAC survey |
| title_full_unstemmed | Evaluation of menstrual irregularities after COVID-19 vaccination: Results of the MECOVAC survey |
| title_short | Evaluation of menstrual irregularities after COVID-19 vaccination: Results of the MECOVAC survey |
| title_sort | evaluation of menstrual irregularities after covid 19 vaccination results of the mecovac survey |
| topic | covid-19 vaccine menstrual irregularities abnormal uterine bleeding adverse effect |
| url | https://doi.org/10.1515/med-2022-0452 |
| work_keys_str_mv | AT laganaantoniosimone evaluationofmenstrualirregularitiesaftercovid19vaccinationresultsofthemecovacsurvey AT veronesigiovanni evaluationofmenstrualirregularitiesaftercovid19vaccinationresultsofthemecovacsurvey AT ghezzifabio evaluationofmenstrualirregularitiesaftercovid19vaccinationresultsofthemecovacsurvey AT ferrariomarcomario evaluationofmenstrualirregularitiesaftercovid19vaccinationresultsofthemecovacsurvey AT cromiantonella evaluationofmenstrualirregularitiesaftercovid19vaccinationresultsofthemecovacsurvey AT bizzarrimariano evaluationofmenstrualirregularitiesaftercovid19vaccinationresultsofthemecovacsurvey AT garzonsimone evaluationofmenstrualirregularitiesaftercovid19vaccinationresultsofthemecovacsurvey AT cosentinomarco evaluationofmenstrualirregularitiesaftercovid19vaccinationresultsofthemecovacsurvey |