Amyloid Beta-Mediated Changes in Synaptic Function and Spine Number of Neocortical Neurons Depend on NMDA Receptors

Amyloid Beta-Mediated Changes in Synaptic Function and Spine Number of Neocortical Neurons Depend on NMDA Receptors

Onset and progression of Alzheimer’s disease (AD) pathophysiology differs between brain regions. The neocortex, for example, is a brain region that is affected very early during AD. NMDA receptors (NMDARs) are involved in mediating amyloid beta (Aβ) toxicity. NMDAR expression, on the other hand, can...

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Bibliographic Details
Main Authors: Michaela K. Back, Sonia Ruggieri, Eric Jacobi, Jakob von Engelhardt
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
5xFAD
Amyloid beta
NMDAR
somatosensory cortex
Online Access:https://www.mdpi.com/1422-0067/22/12/6298

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