Women and Autoimmune Diseases
Autoimmune diseases affect approximately 8% of the population, 78% of whom are women. The reasons for the high prevalence in women are unknown, but circumstantial evidence links autoimmune diseases with preceding infections. Animal models of autoimmune diseases have shown that infections can induce...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2004-11-01
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| Series: | Emerging Infectious Diseases |
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| Online Access: | https://wwwnc.cdc.gov/eid/article/10/11/04-0367_article |
| _version_ | 1818555949070155776 |
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| author | DeLisa Fairweather Noel R. Rose |
| author_facet | DeLisa Fairweather Noel R. Rose |
| author_sort | DeLisa Fairweather |
| collection | DOAJ |
| description | Autoimmune diseases affect approximately 8% of the population, 78% of whom are women. The reasons for the high prevalence in women are unknown, but circumstantial evidence links autoimmune diseases with preceding infections. Animal models of autoimmune diseases have shown that infections can induce autoimmune disease. For example, coxsackievirus B3 (CB3) infection of susceptible mice results in inflammation of the heart (myocarditis) that resembles myocarditis in humans. The same disease can be induced by injecting mice with heart proteins mixed with adjuvant(s), which indicates that an active infection is not necessary for the development of autoimmune disease. We have found that CB3 triggers autoimmune disease in susceptible mice by stimulating elevated levels of proinflammatory cytokines from mast cells during the innate immune response. Sex hormones may further amplify this hyperimmune response to infection in susceptible persons, which leads to an increased prevalence of autoimmune diseases in women. |
| first_indexed | 2024-12-13T13:59:04Z |
| format | Article |
| id | doaj.art-22b8a3052e9543ef803145f70b911f44 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-13T13:59:04Z |
| publishDate | 2004-11-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-22b8a3052e9543ef803145f70b911f442022-12-21T23:42:48ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592004-11-0110112005201110.3201/eid1011.040367Women and Autoimmune DiseasesDeLisa FairweatherNoel R. RoseAutoimmune diseases affect approximately 8% of the population, 78% of whom are women. The reasons for the high prevalence in women are unknown, but circumstantial evidence links autoimmune diseases with preceding infections. Animal models of autoimmune diseases have shown that infections can induce autoimmune disease. For example, coxsackievirus B3 (CB3) infection of susceptible mice results in inflammation of the heart (myocarditis) that resembles myocarditis in humans. The same disease can be induced by injecting mice with heart proteins mixed with adjuvant(s), which indicates that an active infection is not necessary for the development of autoimmune disease. We have found that CB3 triggers autoimmune disease in susceptible mice by stimulating elevated levels of proinflammatory cytokines from mast cells during the innate immune response. Sex hormones may further amplify this hyperimmune response to infection in susceptible persons, which leads to an increased prevalence of autoimmune diseases in women.https://wwwnc.cdc.gov/eid/article/10/11/04-0367_articleautoimmunitymyocarditiscytokinesinnate immunityvirus hormonesconference report |
| spellingShingle | DeLisa Fairweather Noel R. Rose Women and Autoimmune Diseases Emerging Infectious Diseases autoimmunity myocarditis cytokines innate immunity virus hormones conference report |
| title | Women and Autoimmune Diseases |
| title_full | Women and Autoimmune Diseases |
| title_fullStr | Women and Autoimmune Diseases |
| title_full_unstemmed | Women and Autoimmune Diseases |
| title_short | Women and Autoimmune Diseases |
| title_sort | women and autoimmune diseases |
| topic | autoimmunity myocarditis cytokines innate immunity virus hormones conference report |
| url | https://wwwnc.cdc.gov/eid/article/10/11/04-0367_article |
| work_keys_str_mv | AT delisafairweather womenandautoimmunediseases AT noelrrose womenandautoimmunediseases |