Detection of rare blood group, Bombay (Oh) phenotype patients and management by acute normovolemic hemodilution
Background: Due to lack of correct blood grouping practices, the rare Bombay Oh phenotype may be missed, subjecting patients to the risk of severe hemolytic transfusion reaction. In the absence of blood donor registry, transfusion management of patients needing immediate surgery is a challenge. This...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Asian Journal of Transfusion Science |
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| Online Access: | http://www.ajts.org/article.asp?issn=0973-6247;year=2015;volume=9;issue=1;spage=74;epage=77;aulast=Shrivastava |
| _version_ | 1818850177810694144 |
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| author | Manisha Shrivastava Seema Navaid A Peethambarakshan Kalpana Agrawal Athar Khan |
| author_facet | Manisha Shrivastava Seema Navaid A Peethambarakshan Kalpana Agrawal Athar Khan |
| author_sort | Manisha Shrivastava |
| collection | DOAJ |
| description | Background: Due to lack of correct blood grouping practices, the rare Bombay Oh phenotype may be missed, subjecting patients to the risk of severe hemolytic transfusion reaction. In the absence of blood donor registry, transfusion management of patients needing immediate surgery is a challenge. This study presents detection of rare Bombay Oh phenotype patients and their management by acute peri-operative acute normovolemic hemodilution (ANH) in a hospital from central India. Materials and Methods: Blood grouping of patients and blood donors with a standard tube method was carried out and samples identified as rare Bombay phenotype were confirmed by saliva inhibition test. Surgical management of cases needing transfusion was done by ANH, as per the British Committee for Standards in Hematology guidelines. Results: The incidence of Bombay phenotype was 0.002% or 1 in 51,924 in the study. Amongst three cases (patients) identified as Bombay phenotype, one was Bombay Oh, Rh negative. Two cases were missed in the first instance and one case actually did not require transfusion. In the absence of a blood donor registry for Bombay phenotype, the cases needing transfusion were successfully managed with ANH in the operation theatre. Conclusion: A simple test like blood grouping should be done with serious intention with incorporation of both forward and reverse grouping, so that no patient receives wrong blood leading to fatal hemolysis due to transfusion. ANH is a cost-effective transfusion option for suitable patients. Appropriate clinical decision making, use of strategies to decrease peri-operative blood losses and cost-effective country based planning could be more widely applied to improve clinical transfusion practice. |
| first_indexed | 2024-12-19T06:44:59Z |
| format | Article |
| id | doaj.art-22baf21b5e9346ecb0fdb93cf07f5f7a |
| institution | Directory Open Access Journal |
| issn | 0973-6247 1998-3565 |
| language | English |
| last_indexed | 2024-12-19T06:44:59Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj.art-22baf21b5e9346ecb0fdb93cf07f5f7a2022-12-21T20:31:55ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652015-01-0191747710.4103/0973-6247.150957Detection of rare blood group, Bombay (Oh) phenotype patients and management by acute normovolemic hemodilutionManisha ShrivastavaSeema NavaidA PeethambarakshanKalpana AgrawalAthar KhanBackground: Due to lack of correct blood grouping practices, the rare Bombay Oh phenotype may be missed, subjecting patients to the risk of severe hemolytic transfusion reaction. In the absence of blood donor registry, transfusion management of patients needing immediate surgery is a challenge. This study presents detection of rare Bombay Oh phenotype patients and their management by acute peri-operative acute normovolemic hemodilution (ANH) in a hospital from central India. Materials and Methods: Blood grouping of patients and blood donors with a standard tube method was carried out and samples identified as rare Bombay phenotype were confirmed by saliva inhibition test. Surgical management of cases needing transfusion was done by ANH, as per the British Committee for Standards in Hematology guidelines. Results: The incidence of Bombay phenotype was 0.002% or 1 in 51,924 in the study. Amongst three cases (patients) identified as Bombay phenotype, one was Bombay Oh, Rh negative. Two cases were missed in the first instance and one case actually did not require transfusion. In the absence of a blood donor registry for Bombay phenotype, the cases needing transfusion were successfully managed with ANH in the operation theatre. Conclusion: A simple test like blood grouping should be done with serious intention with incorporation of both forward and reverse grouping, so that no patient receives wrong blood leading to fatal hemolysis due to transfusion. ANH is a cost-effective transfusion option for suitable patients. Appropriate clinical decision making, use of strategies to decrease peri-operative blood losses and cost-effective country based planning could be more widely applied to improve clinical transfusion practice.http://www.ajts.org/article.asp?issn=0973-6247;year=2015;volume=9;issue=1;spage=74;epage=77;aulast=ShrivastavaAcute normovolemic hemodilutionBombay Oh phenotypehemolytic transfusion reaction |
| spellingShingle | Manisha Shrivastava Seema Navaid A Peethambarakshan Kalpana Agrawal Athar Khan Detection of rare blood group, Bombay (Oh) phenotype patients and management by acute normovolemic hemodilution Asian Journal of Transfusion Science Acute normovolemic hemodilution Bombay Oh phenotype hemolytic transfusion reaction |
| title | Detection of rare blood group, Bombay (Oh) phenotype patients and management by acute normovolemic hemodilution |
| title_full | Detection of rare blood group, Bombay (Oh) phenotype patients and management by acute normovolemic hemodilution |
| title_fullStr | Detection of rare blood group, Bombay (Oh) phenotype patients and management by acute normovolemic hemodilution |
| title_full_unstemmed | Detection of rare blood group, Bombay (Oh) phenotype patients and management by acute normovolemic hemodilution |
| title_short | Detection of rare blood group, Bombay (Oh) phenotype patients and management by acute normovolemic hemodilution |
| title_sort | detection of rare blood group bombay oh phenotype patients and management by acute normovolemic hemodilution |
| topic | Acute normovolemic hemodilution Bombay Oh phenotype hemolytic transfusion reaction |
| url | http://www.ajts.org/article.asp?issn=0973-6247;year=2015;volume=9;issue=1;spage=74;epage=77;aulast=Shrivastava |
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