Allogeneic DNT cell therapy synergizes with T cells to promote anti-leukemic activities while suppressing GvHD

Abstract Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a second-line treatment with curative potential for leukemia patients. However, the prognosis of allo-HSCT patients with disease relapse or graft-versus-host disease (GvHD) is poor. CD4+ or CD8+ conventional T (Tconv) cells a...

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Bibliographische Detailangaben
Hauptverfasser: Jongbok Lee, Hyeonjeong Kang, Branson Chen, Yoosu Na, Ismat Khatri, Fraser Soares, Housheng Hansen He, Arjun D. Law, Tianzhong Pan, Armin Gerbitz, Xiaoyu Zhu, Mark D. Minden, Li Zhang
Format: Artikel
Sprache:English
Veröffentlicht: BMC 2025-01-01
Schriftenreihe:Journal of Experimental & Clinical Cancer Research
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Online Zugang:https://doi.org/10.1186/s13046-024-03247-w