Comparative In Vitro Controlled Release Studies on the Chronobiotic Hormone Melatonin from Cyclodextrins-Containing Matrices and Cyclodextrin: Melatonin Complexes

Comparative In Vitro Controlled Release Studies on the Chronobiotic Hormone Melatonin from Cyclodextrins-Containing Matrices and Cyclodextrin: Melatonin Complexes

A series of hydrophilic matrix tablets was prepared and tested with respect to their ability to release the hormone melatonin in a controlled manner, in order to alleviate sleep onset and sleep maintenance dysfunctions. Besides the active ingredient, the tablets were comprised of combinations of the...

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Bibliographic Details
Main Authors: Marilena Vlachou, Marianna Papamichael, Angeliki Siamidi, Irene Fragouli, Pandelis A. Afroudakis, Rodanthi Kompogennitaki, Yannis Dotsikas
Format: Article
Language:English
Published: MDPI AG 2017-07-01
Series:International Journal of Molecular Sciences
Subjects:
melatonin
cyclodextrins
NMR studies
in vitro controlled release
Online Access:https://www.mdpi.com/1422-0067/18/8/1641

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