Serum Irisin level in patients undergoing different Stages of Chronic Kidney Disease
Background: Irisin is a myokine that regulates energy metabolism by inducing browning of adipose tissue. The aim of this study was to evaluate the relationship between irisin level and biochemical parameters of chronic kidney disease (CKD) patients in stage 2 and stage 4. Methods: The research was a...
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2019-06-01
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| Series: | Caspian Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://caspjim.com/article-1-1721-en.html |
| _version_ | 1818263213514424320 |
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| author | Javad Sadeghishad Roghayeh Akbari Durdi Qujeq karimollah Hajian |
| author_facet | Javad Sadeghishad Roghayeh Akbari Durdi Qujeq karimollah Hajian |
| author_sort | Javad Sadeghishad |
| collection | DOAJ |
| description | Background: Irisin is a myokine that regulates energy metabolism by inducing browning of adipose tissue. The aim of this study was to evaluate the relationship between irisin level and biochemical parameters of chronic kidney disease (CKD) patients in stage 2 and stage 4.
Methods: The research was a cross-sectional study; the study population included patients with CKD who were over 18 years of age, included 90 individuals with CKD, of these participants, 45 were in the second stage of the CKD while the other 45 subjects were in the fourth stage. Serum irisin concentration plus the level of glucose (Glu), urea, creatinine (Cr) and hemoglobin (Hb) were measured.
Results: In the present study, the serum irisin level of patients in stage 4 was significantly reduced (13.00 ng / ml) compared with patients in stage 2(21.41 ng / ml).
Conclusion: With the progression of CKD from stage 2 to stage 4, parameters such as serum Cr, TG, LDL, FBS, BUN and urea levels significantly increased. Inversely, factors such as irisin, GFR, Alb, HDL and Hb levels significantly decreased. These findings suggest that irisin may be involved in the regulation of biochemical factor levels in CKD patients through the progression from stage 2 to stage 4. |
| first_indexed | 2024-12-12T19:15:27Z |
| format | Article |
| id | doaj.art-22bd6dfbbe5043a58e504844c5f67763 |
| institution | Directory Open Access Journal |
| issn | 2008-6164 2008-6172 |
| language | English |
| last_indexed | 2024-12-12T19:15:27Z |
| publishDate | 2019-06-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Internal Medicine |
| spelling | doaj.art-22bd6dfbbe5043a58e504844c5f677632022-12-22T00:14:45ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722019-06-01103314319Serum Irisin level in patients undergoing different Stages of Chronic Kidney DiseaseJavad Sadeghishad0Roghayeh Akbari1Durdi Qujeq2karimollah Hajian3 Student Research Committee, Babol University of Medical Sciences, Babol, Iran Department of Internal Medicine, Babol University of Medical Sciences, Babol, Iran Cellular and Molecular Biology Research Center (CMBRC), Health Research Institute, Babol University of Medical Sciences, Babol, Iran Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Background: Irisin is a myokine that regulates energy metabolism by inducing browning of adipose tissue. The aim of this study was to evaluate the relationship between irisin level and biochemical parameters of chronic kidney disease (CKD) patients in stage 2 and stage 4. Methods: The research was a cross-sectional study; the study population included patients with CKD who were over 18 years of age, included 90 individuals with CKD, of these participants, 45 were in the second stage of the CKD while the other 45 subjects were in the fourth stage. Serum irisin concentration plus the level of glucose (Glu), urea, creatinine (Cr) and hemoglobin (Hb) were measured. Results: In the present study, the serum irisin level of patients in stage 4 was significantly reduced (13.00 ng / ml) compared with patients in stage 2(21.41 ng / ml). Conclusion: With the progression of CKD from stage 2 to stage 4, parameters such as serum Cr, TG, LDL, FBS, BUN and urea levels significantly increased. Inversely, factors such as irisin, GFR, Alb, HDL and Hb levels significantly decreased. These findings suggest that irisin may be involved in the regulation of biochemical factor levels in CKD patients through the progression from stage 2 to stage 4.http://caspjim.com/article-1-1721-en.htmlChronic kidney diseaseirisinstage |
| spellingShingle | Javad Sadeghishad Roghayeh Akbari Durdi Qujeq karimollah Hajian Serum Irisin level in patients undergoing different Stages of Chronic Kidney Disease Caspian Journal of Internal Medicine Chronic kidney disease irisin stage |
| title | Serum Irisin level in patients undergoing different Stages of Chronic Kidney Disease |
| title_full | Serum Irisin level in patients undergoing different Stages of Chronic Kidney Disease |
| title_fullStr | Serum Irisin level in patients undergoing different Stages of Chronic Kidney Disease |
| title_full_unstemmed | Serum Irisin level in patients undergoing different Stages of Chronic Kidney Disease |
| title_short | Serum Irisin level in patients undergoing different Stages of Chronic Kidney Disease |
| title_sort | serum irisin level in patients undergoing different stages of chronic kidney disease |
| topic | Chronic kidney disease irisin stage |
| url | http://caspjim.com/article-1-1721-en.html |
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