Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp.
Abstract: Cyclostellettamines A – F (1 – 6) isolated from the sponge Pachychalina sp. and cyclostellettamines G - I, K and L (7 – 11) obtained by synthesis were evaluated in bioassays of antimicrobial activity against susceptible and antibiotic-resistant Staphylococcus aureus, Pseudom...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2006-01-01
|
| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/4/1/1/ |
| _version_ | 1798006294325493760 |
|---|---|
| author | Roberto G. S. Berlinck Eduardo Hajdu Célio L. Silva Fabio C. S. Galetti Paulo R. R. Minarini Ana OlÃÂvia de Souza Elissa G. O. Silva Ana Claudia T. Martins Gislene G.F. Nascimento Matthias Köck Achim Grube Christoph Timm Mirna H. R. Seleghim Jaine H. H. L. de Oliveira |
| author_facet | Roberto G. S. Berlinck Eduardo Hajdu Célio L. Silva Fabio C. S. Galetti Paulo R. R. Minarini Ana OlÃÂvia de Souza Elissa G. O. Silva Ana Claudia T. Martins Gislene G.F. Nascimento Matthias Köck Achim Grube Christoph Timm Mirna H. R. Seleghim Jaine H. H. L. de Oliveira |
| author_sort | Roberto G. S. Berlinck |
| collection | DOAJ |
| description | Abstract: Cyclostellettamines A – F (1 – 6) isolated from the sponge Pachychalina sp. and cyclostellettamines G - I, K and L (7 – 11) obtained by synthesis were evaluated in bioassays of antimicrobial activity against susceptible and antibiotic-resistant Staphylococcus aureus, Pseudomonas aeruginosa and antibiotic-susceptible Escherichia coli and Candida albicans, as well as in antimycobacterial activity against Mycobacterium tuberculosis H37Rv bioassays. The results obtained indicated that cyclostellettamines display different antimicrobial activity depending on the alkyl-chain size, suggesting that, if a mechanism-of action is implied, it is dependent on the distance between the two pyridinium moieties of cyclostellettamines. |
| first_indexed | 2024-04-11T12:52:49Z |
| format | Article |
| id | doaj.art-22bef82e7e4743c7bf859b18611bc030 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T12:52:49Z |
| publishDate | 2006-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-22bef82e7e4743c7bf859b18611bc0302022-12-22T04:23:09ZengMDPI AGMarine Drugs1660-33972006-01-01411810.3390/md401001Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp.Roberto G. S. BerlinckEduardo HajduCélio L. SilvaFabio C. S. GalettiPaulo R. R. MinariniAna OlÃÂvia de SouzaElissa G. O. SilvaAna Claudia T. MartinsGislene G.F. NascimentoMatthias KöckAchim GrubeChristoph TimmMirna H. R. SeleghimJaine H. H. L. de OliveiraAbstract: Cyclostellettamines A – F (1 – 6) isolated from the sponge Pachychalina sp. and cyclostellettamines G - I, K and L (7 – 11) obtained by synthesis were evaluated in bioassays of antimicrobial activity against susceptible and antibiotic-resistant Staphylococcus aureus, Pseudomonas aeruginosa and antibiotic-susceptible Escherichia coli and Candida albicans, as well as in antimycobacterial activity against Mycobacterium tuberculosis H37Rv bioassays. The results obtained indicated that cyclostellettamines display different antimicrobial activity depending on the alkyl-chain size, suggesting that, if a mechanism-of action is implied, it is dependent on the distance between the two pyridinium moieties of cyclostellettamines.http://www.mdpi.com/1660-3397/4/1/1/alkaloidsantimycobacterialantibacterialPachychalina sp.sponge |
| spellingShingle | Roberto G. S. Berlinck Eduardo Hajdu Célio L. Silva Fabio C. S. Galetti Paulo R. R. Minarini Ana OlÃÂvia de Souza Elissa G. O. Silva Ana Claudia T. Martins Gislene G.F. Nascimento Matthias Köck Achim Grube Christoph Timm Mirna H. R. Seleghim Jaine H. H. L. de Oliveira Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp. Marine Drugs alkaloids antimycobacterial antibacterial Pachychalina sp. sponge |
| title | Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp. |
| title_full | Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp. |
| title_fullStr | Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp. |
| title_full_unstemmed | Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp. |
| title_short | Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp. |
| title_sort | antimicrobial and antimycobacterial activity of cyclostellettamine alkaloids from sponge pachychalina sp |
| topic | alkaloids antimycobacterial antibacterial Pachychalina sp. sponge |
| url | http://www.mdpi.com/1660-3397/4/1/1/ |
| work_keys_str_mv | AT robertogsberlinck antimicrobialandantimycobacterialactivityofcyclostellettaminealkaloidsfromspongepachychalinasp AT eduardohajdu antimicrobialandantimycobacterialactivityofcyclostellettaminealkaloidsfromspongepachychalinasp AT caƒaliolsilva antimicrobialandantimycobacterialactivityofcyclostellettaminealkaloidsfromspongepachychalinasp AT fabiocsgaletti antimicrobialandantimycobacterialactivityofcyclostellettaminealkaloidsfromspongepachychalinasp AT paulorrminarini antimicrobialandantimycobacterialactivityofcyclostellettaminealkaloidsfromspongepachychalinasp AT anaolaƒaviadesouza antimicrobialandantimycobacterialactivityofcyclostellettaminealkaloidsfromspongepachychalinasp AT elissagosilva antimicrobialandantimycobacterialactivityofcyclostellettaminealkaloidsfromspongepachychalinasp AT anaclaudiatmartins antimicrobialandantimycobacterialactivityofcyclostellettaminealkaloidsfromspongepachychalinasp AT gislenegfnascimento antimicrobialandantimycobacterialactivityofcyclostellettaminealkaloidsfromspongepachychalinasp AT matthiaskaƒack antimicrobialandantimycobacterialactivityofcyclostellettaminealkaloidsfromspongepachychalinasp AT achimgrube antimicrobialandantimycobacterialactivityofcyclostellettaminealkaloidsfromspongepachychalinasp AT christophtimm antimicrobialandantimycobacterialactivityofcyclostellettaminealkaloidsfromspongepachychalinasp AT mirnahrseleghim antimicrobialandantimycobacterialactivityofcyclostellettaminealkaloidsfromspongepachychalinasp AT jainehhldeoliveira antimicrobialandantimycobacterialactivityofcyclostellettaminealkaloidsfromspongepachychalinasp |