The Kinetic Mechanism of 3′-5′ Exonucleolytic Activity of AP Endonuclease Nfo from <i>E. coli</i>

The Kinetic Mechanism of 3′-5′ Exonucleolytic Activity of AP Endonuclease Nfo from <i>E. coli</i>

<i>Escherichia coli</i> apurinic/apyrimidinic (AP) endonuclease Nfo is one of the key participants in DNA repair. The principal biological role of this enzyme is the recognition and hydrolysis of AP sites, which arise in DNA either as a result of the spontaneous hydrolysis of an N-glycos...

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Bibliographic Details
Main Authors: Svetlana I. Senchurova, Aleksandra A. Kuznetsova, Alexander A. Ishchenko, Murat Saparbaev, Olga S. Fedorova, Nikita A. Kuznetsov
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
DNA repair
apurinic/apyrimidinic endonuclease
pre-steady-state kinetics
fluorescence
Online Access:https://www.mdpi.com/2073-4409/11/19/2998

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