Identification of novel genes and altered signaling pathways in the retinal pigment epithelium during the Royal College of Surgeons rat retinal degeneration

Identification of novel genes and altered signaling pathways in the retinal pigment epithelium during the Royal College of Surgeons rat retinal degeneration

Shed photoreceptor outer segments (POS) are phagocytosed by RPE cells in a circadian manner. The homozygous deletion of the c-mer gene abolishes the ingestion phase of this phagocytosis in the Royal College of Surgeons (RCS) rat strain, which in turn leads to the death of photoreceptor cells. We ide...

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Bibliographic Details
Main Authors: Eric M Dufour, Emeline Nandrot, Dominique Marchant, Loïc Van Den Berghe, Stéphanie Gadin, Moussa Issilame, Jean-Louis Dufier, Cécile Marsac, Deborah Carper, Maurice Menasche, Marc Abitbol
Format: Article
Language:English
Published: Elsevier 2003-11-01
Series:Neurobiology of Disease
Subjects:
RCS rat
Phagocytosis
Differential display
Microarray
Retinal pigment epithelium
Gene expression
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103001025

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