The Kisspeptin System in Male Reproduction
The kisspeptin system includes the cleavage products Kiss1 precursor and kisspeptin receptor (Kiss1R). It was originally discovered and studied in cancer metastasis, but the identification of <i>KISS1/KISS1R</i> gene mutations causing hypogonadotropic hypogonadism (HH) revealed unexpecte...
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| Format: | Članak |
| Jezik: | English |
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MDPI AG
2022-04-01
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| Serija: | Endocrines |
| Teme: | |
| Online pristup: | https://www.mdpi.com/2673-396X/3/2/15 |
| _version_ | 1827660628215463936 |
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| author | Rosaria Meccariello |
| author_facet | Rosaria Meccariello |
| author_sort | Rosaria Meccariello |
| collection | DOAJ |
| description | The kisspeptin system includes the cleavage products Kiss1 precursor and kisspeptin receptor (Kiss1R). It was originally discovered and studied in cancer metastasis, but the identification of <i>KISS1/KISS1R</i> gene mutations causing hypogonadotropic hypogonadism (HH) revealed unexpected effects in reproduction. Nowadays, the kisspeptin system is the main central gatekeeper of the reproductive axis at puberty and adulthood, but it also has a widespread functional role in the control of endocrine functions. At the periphery, Kiss1 and Kiss1R are expressed in the testes, but the need for kisspeptin signaling for spermatogenesis and sperm quality is still unclear and debated. This brief manuscript summarizes the main findings on kisspeptin and male reproduction; upcoming data on sperm maturation are also discussed. |
| first_indexed | 2024-03-09T23:55:12Z |
| format | Article |
| id | doaj.art-22bfffdc172f4c8e9a3459c474e6370a |
| institution | Directory Open Access Journal |
| issn | 2673-396X |
| language | English |
| last_indexed | 2024-03-09T23:55:12Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Endocrines |
| spelling | doaj.art-22bfffdc172f4c8e9a3459c474e6370a2023-11-23T16:26:39ZengMDPI AGEndocrines2673-396X2022-04-013216817410.3390/endocrines3020015The Kisspeptin System in Male ReproductionRosaria Meccariello0Department of Movement Sciences and Wellness, University of Naples Parthenope, 80133 Naples, ItalyThe kisspeptin system includes the cleavage products Kiss1 precursor and kisspeptin receptor (Kiss1R). It was originally discovered and studied in cancer metastasis, but the identification of <i>KISS1/KISS1R</i> gene mutations causing hypogonadotropic hypogonadism (HH) revealed unexpected effects in reproduction. Nowadays, the kisspeptin system is the main central gatekeeper of the reproductive axis at puberty and adulthood, but it also has a widespread functional role in the control of endocrine functions. At the periphery, Kiss1 and Kiss1R are expressed in the testes, but the need for kisspeptin signaling for spermatogenesis and sperm quality is still unclear and debated. This brief manuscript summarizes the main findings on kisspeptin and male reproduction; upcoming data on sperm maturation are also discussed.https://www.mdpi.com/2673-396X/3/2/15Kiss1Kiss1 receptorreproductionspermatogenesisepididymisspermatozoa |
| spellingShingle | Rosaria Meccariello The Kisspeptin System in Male Reproduction Endocrines Kiss1 Kiss1 receptor reproduction spermatogenesis epididymis spermatozoa |
| title | The Kisspeptin System in Male Reproduction |
| title_full | The Kisspeptin System in Male Reproduction |
| title_fullStr | The Kisspeptin System in Male Reproduction |
| title_full_unstemmed | The Kisspeptin System in Male Reproduction |
| title_short | The Kisspeptin System in Male Reproduction |
| title_sort | kisspeptin system in male reproduction |
| topic | Kiss1 Kiss1 receptor reproduction spermatogenesis epididymis spermatozoa |
| url | https://www.mdpi.com/2673-396X/3/2/15 |
| work_keys_str_mv | AT rosariameccariello thekisspeptinsysteminmalereproduction AT rosariameccariello kisspeptinsysteminmalereproduction |